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:: Volume 32, Issue 1 (4-2024) ::
Journal of Ilam University of Medical Sciences 2024, 32(1): 26-34 Back to browse issues page
Study of clinical and biomechanical effect of carboxymethyl ellulose on surgical wound healing
Aboutorab Tabatabaei Naeini Tabatabaei Naeini * 1, Massoud Salachi2 , Dorsa Zahedtalab2
1- Clinical Sciences Department, Veterinary Medicine University, Shiraz University, Shiraz, Iran , t-naeini@shirazu.ac.ir
2- Clinical Sciences Department, Veterinary Medicine University, Shiraz University, Shiraz, Iran
Abstract:   (216 Views)
Introduction:  : One of the most important problems and complications after surgery is tissue adhesion. Carboxymethyl cellulose is a cellulose derivative that can dissolve in water and has high viscosity. In this study, the role and effect of carboxymethyl cellulose in the healing of surgical wounds in rabbits have been discussed.
Material & Methods: To conduct the study, 15 male rabbits aged 7-9 months were randomly divided into 3 groups of 5: experimental, control, and skin wound. After preparing the operation site, in both the control and experimental groups, a 4 cm incision was made in the right flank region. In the experimental group, the inside of the abdominal cavity was smeared with carboxymethyl cellulose gel (dose 7 mg/kg); however, in the control group, carboxymethyl cellulose gel was not used. Two groups of abdominal cavity slits were sewn in two separate layers. In the skin wound group, only the skin was cut, and then the wound was covered with carboxymethyl cellulose and sutured. The surface of the wounds was clinically examined daily, and on the 20th day, skin and muscle samples were taken for biomechanical studies.
Results: The results showed that, clinically, the wound was repaired in the same way in the three groups, and carboxymethyl cellulose had no difference in the biomechanical parameters, maximum tensile strength, and tissue stiffness, in the skin tissue between the groups, and besides preventing tissue adhesion, it increased the biomechanical parameters in the muscle tissue.
Discussion & Conclusion: According to the results, carboxymethyl cellulose had no negative effect on the healing process of the skin and led to better healing and strength of the muscle tissue.
Keywords: biomechanical parameters, carboxymethyl cellulose, rabbit, wound healing
Full-Text [PDF 411 kb]   (134 Downloads)    
Type of Study: Research | Subject: General surgery
Received: 2023/06/29 | Accepted: 2023/12/18 | Published: 2024/05/4
1. Singh S, Young A, McNaught CE. The physiology of wound healing. Surgery (Oxford) 2017;35:473-7. doi:10.1016/j.mpsur.2017.06.004.
2. Ho AW, Kupper TS. T cells and the skin: from protective immunity to inflammatory skin disorders. Nat Rev Immunol 2019;19:490-502. doi: 10.1038/s41577-019-0162-3.
3. Qu J, Zhao X, Liang Y, Xu Y, Ma PX, Guo B. Degradable conductive injectable hydrogels as novel antibacterial, anti-oxidant wound dressings for wound healing. Chem Eng J 2019;362:548-60.doi: 10.1016/j.cej.2019.01.028.
4. Monavarian M, Kader S, Moeinzadeh S, Jabbari E. Regenerative scar-free skin wound healing. Tissue Eng Part B Rev 2019;25:294-311.doi: 10.1089/ten.teb.2018.0350.
5. Rennert RC, Rodrigues M, Wong VW, Duscher D, Hu M, Maan Z, et al. Biological therapies for the treatment of cutaneous wounds: phase III and launched therapies. Expert Opin Biol Ther 2013;13:1523-41.doi:10.1517/14712598.2013.842972.
6. Prakashan D, Roberts A, Gandhi S. Recent advancement of nanotherapeutics in accelerating chronic wound healing process for surgical wounds and diabetic ulcers. Biotechnol Genet Eng Rev 2023:1-29.doi:10.1080/02648725.2023.2167432.
7. Robertson JT. Conditions of the stomach and small intestine: differential diagnosis and surgical management. Vet Clin North Am Large Anim Pract 1982;4:105-27. doi:10.1016/s0196-9846(17)30121-0.
8. Stommel MW, Ten Broek RP, Strik C, Slooter GD, Verhoef C, Grünhagen DJ, et al. Multicenter observational study of adhesion formation after open-and laparoscopic surgery for colorectal cancer. Ann Surg 2018;267:743-8. doi:10.1097/SLA.0000000000002175.
9. Fatehi Hassanabad A, Zarzycki AN, Jeon K, Deniset JF, Fedak PW. Post-operative adhesions: a comprehensive review of mechanisms. Biomedicines 2021;9:867. doi:10.3390/biomedicines9080867.
10. Kheilnezhad B, Hadjizadeh A. A review: progress in preventing tissue adhesions from a biomaterial perspective. Biomater Sci 2021;9:2850-73. doi:10.1039/D0BM02023K.
11. Mueller PO, Hunt RJ, Allen D, Parks AH, Hay WP. Intraperitoneal use of sodium carboxymethylcellulose in horses undergoing exploratory celiotomy. Vet Surg 1995; 24:112-7. doi: 10.1111/j.1532-950x.1995.tb01304.x.
12. Hay WP, Mueller PE, Harmon B, Amoroso L. One percent sodium carboxymethylcellulose prevents experimentally induced abdominal adhesions in horses. Vet Surg 2001;30:223-7. doi:10.1053/jvet.2001.17849.
13. An JM, Shahriar SS, Hasan MN, Cho S, Lee YK. Carboxymethyl cellulose, pluronic, and pullulan-based compositions efficiently enhance antiadhesion and tissue regeneration properties without using any drug molecules. ACS Appl Mater Interfaces 2021;13:15992-6006. doi: 10.1021/acsami.0c21938.
14. Kaur P, Bohidar HB, Nisbet DR, Pfeffer FM, Rifai A, Williams R, et al. Waste to high-value products: The performance and potential of carboxymethylcellulose hydrogels via the circular economy. Cellulose 2023;30:2713-30. doi:10.1007/s10570-023-05068-0.
15. Zhang W, Liu Y, Xuan Y, Zhang S. Synthesis and applications of carboxymethyl cellulose hydrogels. Gels 2022;8:529. doi: 10.3390/gels8090529.
16. Bhat MA, Rather RA, Yaseen Z, Shalla AH. Viscoelastic and smart swelling disposition of Carboxymethylcellulose based hydrogels substantiated by Gemini surfactant and in-vitro encapsulation and controlled release of Quercetin. Int J Biol Macromol 2022 ;207:374-86. doi:10.1016/j.ijbiomac.2022.02.162.
17. Huang YC, Liu ZH, Kuo CY, Chen JP. Photo-Crosslinked Hyaluronic Acid/Carboxymethyl Cellulose Composite Hydrogel as a Dural Substitute to Prevent Post-Surgical Adhesion. Int J Mol Sci 2022;23:6177. doi: 10.3390/ijms23116177.
18. Fredericks CM, Kotry I, Holtz G, Askalani AH, Serour GI. Adhesion prevention in the rabbit with sodium carboxymethylcellulose solutions. Am J Obstet Gynecol 1986;155:667-70. doi: 10.1016/0002-9378(86)90304-2.
19. Mueller PE, Harmon BG, Hay WP, Amoroso LM. Effect of carboxymethylcellulose and a hyaluronate-carboxymethylcellulose membrane on healing of intestinal anastomoses in horses. Am J Vet Res 2000;61:369-74. doi: 10.2460/ajvr.2000.61.369.
20. Yamaner S, Kalayci M, Barbaros U, Balik E, Bulut T. Does hyaluronic acid-carboxymethylcellulose (HA-CMC) membrane interfere with the healing of intestinal suture lines and abdominal incisions? Surg Innov 2005;12:37-41. doi:10.1177/155335060501200106.
21. Bang S, Ko YG, Kim WI, Cho D, Park WH, Kwon OH. Preventing postoperative tissue adhesion using injectable carboxymethyl cellulose-pullulan hydrogels. Int J Biol Macromol 2017;105:886-93. doi:10.1016/j.ijbiomac.2017.07.103.
22. Ferner RE. Martindale's Extra Pharmacopoeia. BMJ 1996;313(7066):1214. doi: 10.1136/bmj.313.7066.1214a.
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Tabatabaei Naeini A T N, Salachi M, Zahedtalab D. Study of clinical and biomechanical effect of carboxymethyl ellulose on surgical wound healing. J. Ilam Uni. Med. Sci. 2024; 32 (1) :26-34
URL: http://sjimu.medilam.ac.ir/article-1-8022-en.html

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Volume 32, Issue 1 (4-2024) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
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