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:: Volume 32, Issue 2 (6-2024) ::
Journal of Ilam University of Medical Sciences 2024, 32(2): 76-87 Back to browse issues page
Simultaneous effect of aerobic exercise and nanocurcumin supplementation on the expression of BDNF and NGF genes in rats with brain tumor
Salmah Mohamadi1 , Hosein Shirvani * 2, Mehdi Roozbahani3 , Masoud Rahmati4
1- Dept of Exercise Physiology, Borujerd Branch, Islamic Azad University, Borujerd, Iran
2- Exercise Physiology Research Center, Lifestyle Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran , shirvani.h2006@gmail.com
3- Dept of Motor Behavior, Borujerd Branch, Islamic Azad University, Borujerd, Iran
4- Dept of Sports Science, Faculty of Literature and Humanities, Lorestan University, Khorramabad, Iran
Abstract:   (405 Views)
Introduction:  Increased nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) signaling in neuroblastoma cells may represent an autocrine system to support cancer growth, invasion, and metastasis. Therefore, this research aimed to assess the simultaneous effect of aerobic exercise and nano curcumin supplementation on the expression of BDNF and NGF genes in rats with brain tumors.
Material & Methods:  A total of 35 male Wistar rats were randomly assigned to seven groups of five: healthy base control, healthy control of 4 weeks, base cancer control, four weeks of cancer control, cancer+nanocolumns, cancer+aerobic, and cancer exercise+aerobic exercise+nanocolumns. After injecting cancer cells into the mice's forehead cortex, with 80 mg/kg supplement gauges for 28 days, five days a week, enter the main aerobic exercise program on the rotating tape for four weeks, three days a week. At 18 m/min, they were 25-40 minutes. In the end, the mice were sacrificed, and data were collected.
Results: The expression of the BDNF gene in the training+nano curcumin group was significantly decreased compared to the baseline cancer control and 4-week cancer (P<0.05). Moreover, the expression of the NGF gene in the exercise group showed a significant decrease compared to the baseline cancer control and 4-week cancer (P<0.05). Nonetheless, no significant difference was observed in the nano curcumin group and nanocurcumin +exercise (P>0.05).
Discussion & Conclusion: It seems that aerobic exercise along with nanocurcumin can possibly increase neurogenesis in rats with brain cancer by reducing BDNF and NGF gene expression through receptors.

 
Keywords: Aerobic training, BDNF, Brain Tumor, Nanocurcumin supplement, NGF
Full-Text [PDF 486 kb]   (136 Downloads)    
Type of Study: Research | Subject: Physical Education
Received: 2023/05/24 | Accepted: 2024/01/10 | Published: 2024/06/4
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Mohamadi S, Shirvani H, Roozbahani M, Rahmati M. Simultaneous effect of aerobic exercise and nanocurcumin supplementation on the expression of BDNF and NGF genes in rats with brain tumor. J. Ilam Uni. Med. Sci. 2024; 32 (2) :76-87
URL: http://sjimu.medilam.ac.ir/article-1-7986-en.html
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Volume 32, Issue 2 (6-2024) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
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