[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
About the Journal
Editorial Board
Aims& Scopes
Journal News
Articles archive::
All Issues
Current Issue
Publication Ethics::
Peer Review Process::
Indexing Databases::
For Authors::
Authors Guideline
Call for Papers
Submission Instruction
Review Process
Research Ethics Statements
Ethical issues
Author Complaint Process
For Reviewers::
Reviewers Section
Subscription::
Registration Information
Subscription Form
Contact us::
Contact Information
Contact us
Site Facilities::
Site map
Search contents
FAQ
Top 10 contents
Inform to friends
::
Google Scholar Metrics

Citation Indices from GS

AllSince 2019
Citations68114049
h-index2721
i10-index20498
..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Registered in

AWT IMAGE

AWT IMAGE
..
:: Volume 31, Issue 3 (8-2023) ::
Journal of Ilam University of Medical Sciences 2023, 31(3): 1-8 Back to browse issues page
Diagnostic challenges of lung biopsies in setting of metastatic female genital tract tumors; report of 2 cases
Fazaneh Fazli Khalaf1 , Vahid Soleimani1 , Tahere Yousefi1 , Shahab Rafieian2 , Behnaz Jahanbin * 3, Sara Rokn4
1- Dept of Pathology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2- Dept of Thoracic Surgery, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
3- Dept of Pathology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran , bjahanbin1358@gmail.com
4- Dept of Chemistry and Biochemistry, University of Windsor, Ontario, Canada
Abstract:   (1081 Views)
Introduction: Lungs are one of the most common sites for metastatic tumors in the body. In addition, primary lung tumors are the most common cause of death due to neoplasms in both genders. Treatment strategies are completely different for primary and metastatic lung tumors making accurate diagnosis of lung tumors an effective factor in planning the correct treatment. The development of personalized medicine and targeted therapy, especially in the treatment of primary lung tumors, has highlighted the importance of correct diagnosis of these tumors.
Case report: The Pathology Center of Imam Khomeini Hospital Cancer Institute in Tehran, Iran, as a referral center for cancer across the country, is faced with a large number of lung biopsies, and therefore, there will be numerous diagnostic challenges. In this article, we presented two cases of primary female genital tract (cervical) tumors that during follow up lung masses were detected. Diagnosis on lung biopsy assigned as primary lung adenocarcinoma. Both cases referred to our lab for second opinion accompanied with related resected sample and implementation of further supplementary markers documented metastatic origin of tumors.
Discussion & conclusion: In both cases, similarity in immunohistochemical characteristics of metastatic tumors with primary lung adenocarcinoma, especially positive nuclear TTF1 staining led to misdiagnosis of lung tumor origin. This finding emphasizes on the use of other specific markers related to primary site of tumor to decrease possibility of incorrect diagnosis of the origin of the tumor in metastatic setting. Due to remarkable influence of primary versus metastatic origin of lung tumor on selection of treatment, pathologists should be considered correct diagnosis and notice to similarity of immunohistochemical markers of primary lung tumors to other organs and implementation of more specific markers are necessary.

 
Keywords: lung tumors, metastatic tumors, immunohistochemistry, TTF1
Full-Text [PDF 971 kb]   (1018 Downloads)    
Type of Study: case report | Subject: Clinical pathology
Received: 2023/04/23 | Accepted: 2023/05/22 | Published: 2023/09/6
References
1. Fisseler-Eckhoff A, Müller KM. Differential diagnosis of primary lung tumors and pulmonary metastases. Verh Dtsch Ges Pathol 2000; 84:106-17.
2. Inamura K. Update on Immunohistochemistry for the Diagnosis of Lung Cancer. Cancers 2018; 10:72. doi: 10.3390/cancers10030072.
3. Jagirdar J. Application of immunohistochemistry to the diagnosis of primary and metastatic carcinoma to the lung. Arch Pathol Lab Med 2008; 132:384-96. doi: 10.5858/2008-132-384-AOITTD.
4. Jeong JH, Kim NY, Pyo JS. Analysis of PAX8 immunohistochemistry in lung cancers: a meta-analysis. J Pathol Transl Med 2020; 54:300-9. doi: 10.4132/jptm.2020.06.08.
5. Jennings CG, Dyer SM, Burden SJ. Muscle-specific trk-related receptor with a kringle domain defines a distinct class of receptor tyrosine kinases. Proc Natl Acad Sci USA 1993; 90:2895-9. doi: 10.1073/pnas.90.7.2895.
6. Yatabe Y, Dacic S, Borczuk AC, Warth A, Russell PA, Lantuejoul S, et al. Best Practices Recommendations for Diagnostic Immunohistochemistry in Lung Cancer. J Thorac Oncol 2019; 14:377-407. doi: 10.1016/j.jtho.2018.12.005.
7. Liang L, Zheng W, Liu J, Liang SX. Assessment of the Utility of PAX8 Immunohistochemical Stain in Diagnosing Endocervical Glandular Lesions. Arch Pathol Lab Med 2016; 140:148-52. doi: 10.5858/arpa.2015-0081-OA.
8. Tachibana M, Saito M, Kobayashi J, Tsutsumi Y. Lung metastasis of endometrioid carcinoma aberrantly expressing thyroid transcription factor-1. Hum Pathol Case Rep 2020; 22:200448. doi: 10.1016/j.ehpc.2020.200448.
9. Zhang PJ, Gao HG, Pasha TL, Litzky L, Livolsi VA. TTF-1 expression in ovarian and uterine epithelial neoplasia and its potential significance, an immunohistochemical assessment with multiple monoclonal antibodies and different secondary detection systems. Int J Gynecol Pathol 2009; 28:10-8. doi: 10.1097/PGP.0b013e3181804bc6.
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA

XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Fazli Khalaf F, Soleimani V, Yousefi T, Rafieian S, Jahanbin B, Rokn S. Diagnostic challenges of lung biopsies in setting of metastatic female genital tract tumors; report of 2 cases. J. Ilam Uni. Med. Sci. 2023; 31 (3) :1-8
URL: http://sjimu.medilam.ac.ir/article-1-7950-en.html
Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 31, Issue 3 (8-2023) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
Persian site map - English site map - Created in 0.1 seconds with 41 queries by YEKTAWEB 4666