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:: Volume 31, Issue 2 (6-2023) ::
Journal of Ilam University of Medical Sciences 2023, 31(2): 86-96 Back to browse issues page
Changes in the Serum Levels of Metabotropic Biomarkers (Asprosin and BDNF) in Adaptation to Aerobic Interval Training
Akbar Ghalavand * 1, Mehdi Mohammadpour2 , Marya Rahmani Ghobadi3 , Pezhman Motamedi4 , Ania Hovsepian5
1- Pediatric Gastroenterology and Hepatology Research Center, Zabol University of Medical Sciences, Zabol, Iran , akbarghalavand@gmail.com
2- Dept of Physical Education, Dezfoul Branch, Islamic Azad University, Dezfoul, Iran
3- Dept of Physical Education and Sport Sciences, Damavand Branch, Islamic Azad University, Damavand, Iran
4- Dept of Exercise Physiology, Faculty of Sport Sciences, Kharazmi University, Tehran, Iran
5- Dept of Exercise Physiology, Faculty of Sport Science, Isfahan University, Isfahan, Iran
Abstract:   (613 Views)
Introduction: Some cytokines, including asprosin and brain-derived neurotrophic factor (BDNF), are metabotropic factors, which play a role in the development of type 2 diabetes. This study aimed to determine the effect of aerobic interval training on the circulating levels of BDNF and asprosin in men with type 2 diabetes.
Material & Methods: In this semi-experimental study, 20 men with type 2 diabetes were selected by random sampling and randomly divided into two experimental and control groups. Exercise training was performed for 12 weeks (three 60-90-min sessions of interval aerobic training). The obtained data were analyzed in SPSS software (version 26) through t-test and ANCOVA (P≤0.05).
Findings: The results showed that after the training intervention, a significant decrease was observed in serum asprosin level (F=7.670; P=0.013), followed by a significant increase in serum levels of BDNF (F=7.585; P=0.014) in the training group, compared to the baseline values and the control group.
Discussion & Conclusion: According to the results of the present study, it can be said that interval aerobic training has an effective role in controlling blood glycemic levels and the treatment of type 2 diabetes by reducing asprosin and increasing BDNF as two metabotropic cytokines.
Keywords: Aerobic interval training, Asprosin, Brain-derived neurotrophic factor, Metabotropic agents, Type 2 diabetes
Full-Text [PDF 1320 kb]   (356 Downloads)    
Type of Study: Research | Subject: physiology
Received: 2022/08/6 | Accepted: 2022/12/4 | Published: 2023/06/5
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Ghalavand A, Mohammadpour M, Rahmani Ghobadi M, Motamedi P, Hovsepian A. Changes in the Serum Levels of Metabotropic Biomarkers (Asprosin and BDNF) in Adaptation to Aerobic Interval Training. J. Ilam Uni. Med. Sci. 2023; 31 (2) :86-96
URL: http://sjimu.medilam.ac.ir/article-1-7675-en.html

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Volume 31, Issue 2 (6-2023) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
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