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:: Volume 30, Issue 5 (12-2022) ::
Journal of Ilam University of Medical Sciences 2022, 30(5): 68-77 Back to browse issues page
Effect of Finasteride on PSA and Histopathological Results in Patients Undergoing Prostate Biopsy
Saman Farshid1 , Ali Tehranchi1 , Amir Jamei2 , Faramarz Ojaghi3 , Farid Kalashipour * 4
1- Dept of Urology, Imam Khomeini Hospital, Urmia, Urmia University of Medical Sciences, Urmia,
2- Dept of Urology, Imam Khomeini Hospital, Urmia, Urmia University of Medical Sciences, Urmia, Iran
3- Dept of Operating Room, Imam Khomeini Hospital Urmia, Urmia University of Medical Sciences, Urmia, Iran
4- Dept of Operating Room, Faculty of Nursing and Midwifery, Kurdistan University of Medical Sciences, Sanandaj, Iran , faridkalashi871@gmail.com
Abstract:   (1739 Views)
Introduction: Prostate cancer management focuses on rapid diagnosis and treatment. The present study was performed to investigate the effect of finasteride on PSA changes and biopsy results.
Material & Methods: This retrospective descriptive-analytical study included 98 patients between the ages of 50 and 75 years with PSA levels between 2.5 and 10 and negative DRE candidates for prostate biopsy. Patients were divided into two groups. The first group consisted of patients who consented to a prostate biopsy based on PSA levels. The second group of patients did not consent to prostate biopsy during referral. Moreover, they tended to delay prostate biopsy. At the end of the three-month period, patients who agreed to prostate biopsy were sampled. The effect of treatment on biopsy results and changes in PSA levels were compared between the two groups.
(Ethic code: IR.UMSU.REC.1396.20)
Findings: Three months after the initiation of the study, the mean PSA level was 3.43±6.11 ng/ml in the case group and 7.36±2.20 in the control group. This difference was statistically significant (P=0.031). After three months of finasteride, the mean total PSA level among those who tested positive for biopsy was 2.41±7.63 ng/ml and among those who tested negative for biopsy was 2.98±6.42 ng/ml. This difference was also statistically significant (P=0.046).
Discussion & Conclusion: The use of finasteride in patients suspected of having prostate cancer for at least three months can lead to a correct decision regarding prostate biopsy and reduce the number of negative prostate cancer results in the biopsy, as well as the burden on the treatment system to use improper prostate biopsy.
 
Keywords: BPH, Finasteride, Prostate Biopsy, Prostate Cancer, Prostate-specific antigen
Full-Text [PDF 947 kb]   (1168 Downloads)    
Type of Study: Research | Subject: General
Received: 2021/10/25 | Accepted: 2022/06/14 | Published: 2022/12/6
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Farshid S, Tehranchi A, Jamei A, Ojaghi F, Kalashipour F. Effect of Finasteride on PSA and Histopathological Results in Patients Undergoing Prostate Biopsy. J. Ilam Uni. Med. Sci. 2022; 30 (5) :68-77
URL: http://sjimu.medilam.ac.ir/article-1-7326-en.html


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Volume 30, Issue 5 (12-2022) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
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