[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
About the Journal
Editorial Board
Aims& Scopes
Journal News
Articles archive::
All Issues
Current Issue
Publication Ethics::
Peer Review Process::
Indexing Databases::
For Authors::
Authors Guideline
Call for Papers
Submission Instruction
Review Process
Research Ethics Statements
Ethical issues
Author Complaint Process
For Reviewers::
Reviewers Section
Subscription::
Registration Information
Subscription Form
Contact us::
Contact Information
Contact us
Site Facilities::
Site map
Search contents
FAQ
Top 10 contents
Inform to friends
::
Google Scholar Metrics

Citation Indices from GS

AllSince 2019
Citations68704104
h-index2822
i10-index20699
..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Registered in

AWT IMAGE

AWT IMAGE
..
:: Volume 28, Issue 6 (1-2021) ::
Journal of Ilam University of Medical Sciences 2021, 28(6): 1-11 Back to browse issues page
Effect of ACE (I/D) and ACTN-3 (R/X) Genotypes on some Factors of Physical Fitness and Performance of Motor Skills in 6-8-Year-Old Children
Omid Mohammadian * 1, Abbas Bahram2 , Farhad Ghadiri2 , Rasool Yaali2 , Zohre Mazaheri tayarani3
1- Dept of Motor Behavior, Faculty of Physical Education and Sport Sciences, Kharazmi University, Tehran, Iran , omohammadian10@gmail.com
2- Dept of Motor Behavior, Faculty of Physical Education and Sport Sciences, Kharazmi University, Tehran, Iran
3- Basic Medical Science Research Center, Histogenotech Co., Tehran, Iran
Abstract:   (2793 Views)
Introduction: The identification of the factors affecting the physical performance and development of children's motor skills can be of great importance in participating in physical activities, preventing overweight and obesity, as well as identifying and guiding the top talented children in sport. Therefore, this study aimed to investigate the effect of different ACE (I/D) and ACTN-3 (R/X) genotypes on some factors of physical fitness and motor skill performance in children.
  
Materials & Methods: The statistical population of this study included 6-8-year-old school children in Tehran, Iran. In total, 50 cases were selected randomly using the cluster-sampling method. The data were collected using the Physical Fitness Test, Test of Gross Motor Development-Third Edition (TGMD-3), and PCR for the determination of ACE and ACTN-3 polymorphism. Furthermore, a one-way analysis of variance and independent t-test were used to analyze the study data. A p-value less than 0.05 was considered statistically significant. 
Ethics code: IR.KHU.REC.1399.010
 
 
Findings: The results showed that children carrying allele D of ACE gene, (DD or ID genotype), compared to those with II genotype (P<0.05), and the cases carrying the allele R of ACTN-3 gene (RR or RX genotype), compared to those with XX genotype (P<0.05) had more muscular strength in hand and foot, as well as higher levels of locomotor skills. However, no significant difference was observed regarding the performance of ball motor skills (P>0.05).
 
Discussions & Conclusions: According to the results of the study, it can be said that the children carrying DD or ID genotype of ACE and RR or RX genotype of ACTN-3 had a higher level of physical development and consequently higher levels of locomotor skill performance. Therefore, if they are provided with desirable environmental conditions, they will be able to do sport skills accompanied by higher levels of performance.
Keywords: Children, Genotype, Motor development, Phenotype, Physical fitness, Sport gene
Full-Text [PDF 899 kb]   (740 Downloads)    
Type of Study: Research | Subject: Physical Education
Received: 2020/07/29 | Accepted: 2020/12/5 | Published: 2021/02/28
References
1. Gallahue DL, Ozmun JC, Goodway J. Understanding motor development infants children adolescents and adults. 1th ed. Mcgraw hill Boston Publication. 2006;P.73-99.
2. Payne VG, Isaacs LD. Human motor development a lifespan approach. 3 th ed. Routledge Publication. 2017;P.231-46.
3. Collins M. Genetics and sports. 2 th ed. Karger Med Sci Publication.2009;P.101-9.
4. Ahmetov II, Gavrilov DN, Astratenkova IV, Druzhevskaya AM, Malinin AV, Romanova EE, et al. The association of ACE andACTN3 and PPARA gene variants with strength phenotypes in middle school age children. J Physiol Sci 2013;63:79-85. doi. 10.1007/s12576-012-0233-8.
5. Bray MS, Hagberg JM, Perusse L, Rankinen T, Roth SM, Wolfarth B, et al. The human gene map for performance and health related fitness phenotypes the 2006-7. Med Sci Sport Exe2009;41:34-72. doi.10.1249/MSS.0b013e3181844179.
6. Williams AG, Day SH, Folland JP, Gohlke P, Dhamrait S, Montgomery HE. Circulating angiotensin converting enzyme activity is correlated with muscle strength. Med Sci Sport Exe 2005;37:944.
7. Ahmetov II, Williams AG, Popov DV, Lyubaeva EV, Hakimullina AM, Fedotovskaya ON, et al. The combined impact of metabolic gene polymorphisms on elite endurance athlete status and related phenotypes. Hum Gene 2009;126:751. doi.10.1007/s00439-009-0728-4.
8. Pereira A, Costa AM, Leitao JC, Monteiro AM, Izquierdo M, Silva AJ, et al. The influence of ACE ID and ACTN3 R577X polymorphisms on lower-extremity function in older women in response to high speed power training. BMC Geriatr2013;13:131.
9. doi.10.1186/1471-2318-13-131.
10. Zehsaz F, Safabakhsh AH, Farhangi N, Keynezhad N, Monfaredan A, Ghahramani M. Do ACE and CKMM gene variations have potent effects on physical performance in inactive male adolescents? Mole Biol Rep2019;46:1835-43.
11. Santoro GF, Mello KD, Oliveira Netto ZC, Pfutzenreuter G, Bassan JC, Salgueirosa FDM. The influence of ace i/d gene polymorphism in amateur american football athletes in brazil. Rev Brasileira Med Esporte2019;25:460-3. doi.10.1590/1517-869220192506198909.
12. Scott RA, Moran C, Wilson RH, Onywera V, Boit MK, Goodwin WH, et al. No association between angiotensin converting enzyme gene variation and endurance athlete status in Kenyans. Comp Biochem Physiol Mole Int Physiol 2005;141:169-75. doi.10.1016/j.cbpb.2005.05.001.
13. Kim K, Ahn N, Cheun W, Byun J, Joo Y. Association of angiotensin converting enzyme I/D and α-actinin-3 R577X genotypes with growth factors and physical fitness in Korean children. Korean J Physiol Pharmacol 2015;19:131-9. doi.10.4196/kjpp.2015.19.2.131.
14. Coso J, Hiam D, Houweling P, Perez LM, Eynon N, Lucia A. More than a speed gene ACTN3 R577X genotype trainability muscle damage and the risk for injuries. European J Appl Physiol 2019;119:49-60.
15. doi.10.1007/s00421-018-4010-0.
16. Erskine RM, Williams AG, Jones DA, Stewart CE, Degens H. The individual and combined influence of ACE and ACTN3 genotypes on muscle phenotypes before and after strength training. Scandinavian J Med Sci Sport 2014;24:642-8. doi.10.1111/sms.12055
17. Yang R, Shen X, Wang Y, Voisin S, Cai G, Fu Y, et al. ACTN3 R577X gene variant is associated with muscle related phenotypes in elite Chinese sprint/power athletes. J Str Cond Res 2017;31:1107-15.
18. doi.10.1519/JSC.0000000000001558.
19. Moran CN, Vassilopoulos C, Tsiokanos A, Jamurtas AZ, Bailey ME, Montgomery HE, et al. The associations of ACE polymorphisms with physical, physiological and skill parameters in adolescents. European J Hum Gene 2006;14:332-9.
20. doi.10.1038/sj.ejhg.5201550
21. Zhang Q, Cao Y, Chen J, Shen J, Ke D, Wang X, et al. ACTN3 is associated with children’s physical fitness in Han Chinese. Mole Gene Genom2019;294:47-56. doi.10.1007/s00438-018-1485-7
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA

Ethics code: IR.KHU.REC.1399.010

XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Mohammadian O, Bahram A, Ghadiri F, Yaali R, Mazaheri tayarani Z. Effect of ACE (I/D) and ACTN-3 (R/X) Genotypes on some Factors of Physical Fitness and Performance of Motor Skills in 6-8-Year-Old Children. J. Ilam Uni. Med. Sci. 2021; 28 (6) :1-11
URL: http://sjimu.medilam.ac.ir/article-1-6694-en.html
Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 28, Issue 6 (1-2021) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
Persian site map - English site map - Created in 0.15 seconds with 41 queries by YEKTAWEB 4671