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:: Volume 27, Issue 1 (4-2019) ::
Journal of Ilam University of Medical Sciences 2019, 27(1): 1-12 Back to browse issues page
Effect of Fennel Extract on the Improvement of Memory Disorders in Beta Amyloid Alzheimer Model of Male Wistar Rats
Delaram Eslimi Esfehani * 1, Shahrbanoo Oryan2 , Maryam Khosravi2 , Farhad Valizadegan3
1- Dept of Animal Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran , eslimid@yahoo.com
2- Dept of Animal Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran
3- Dept of Biology, Faculty of Sciences, Mazandaran University, Babolsar, Iran
Abstract:   (4729 Views)
Introduction: Alzheimer's disease is the most common neurodegenerative disorder. Due to the neurodegenerative effect of fennel (Foeniculum vulgare) this study aimed at investigating the effect of this plant on the improvement of learning and memory in rat models of Alzheimer's disease. 


Material & Methods: The male Wistar rats were assigned into six groups, namely the control group (no injection), sham group (saline injection), experimental group (injection of beta-amyloid (40-1). The other three groups received 75, 140, and 250 ml/kg of fennel extract intraperitoneally 7 days before and 3 weeks after bilateral intraventricular beta-amyloid injection. Shuttle box was used to study the learning and memory behavior of the rats; moreover hematoxylin-eosin staining was conducted for histological studies.
 
Findings: According to the results, fennel extract at a dose of 140 mg/kg increased behavioral indicators in measuring the passive avoidance memory in the Alzheimer's group, compared to the sham group (P<0.001). Moreover, optical microscopy studies showed a significant decrease in tissue damage and an increase in the number of Nissl bodies stained in CA1 hippocampal region, especially in pyramidal layer, in Alzheimer's disease-induced rats treated with fennel extract at a dose of 140 mg/kg.


Discussion & Conclusions: In this study, fennel extract shows the neuroprotective effect against Alzheimer’s disease induced by beta-amyloid (40-1). the observed improvements are probably related with antioxidant, anti-inflammatory, and pseudo-estrogenic properties of this plant. 
Keywords: Alzheimer’s disease, Beta-amyloid, Passive avoidance memory, Rat, Shuttle box
Full-Text [PDF 1054 kb]   (1509 Downloads)    
Type of Study: Research |
Received: 2017/12/12 | Accepted: 2018/05/28 | Published: 2019/04/15
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Eslimi Esfehani D, Oryan S, Khosravi M, Valizadegan F. Effect of Fennel Extract on the Improvement of Memory Disorders in Beta Amyloid Alzheimer Model of Male Wistar Rats . J. Ilam Uni. Med. Sci. 2019; 27 (1) :1-12
URL: http://sjimu.medilam.ac.ir/article-1-4717-en.html


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Volume 27, Issue 1 (4-2019) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
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