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:: Volume 26, Issue 4 (11-2018) ::
Journal of Ilam University of Medical Sciences 2018, 26(4): 166-174 Back to browse issues page
Effect of Two-Week Swimming Training on the Expression of Irisin Protein in Lumbar Spine of Rats with Neuropathic Pain
Babak Farzad1 , Nabi Shamsaei2, Hamid Rajabi3, Reza Gharakhanlou4, Seyed Behnamedin Jameie * 5
1- Neuroscience Research Center, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran.
2- Dept of Physical Education and Sports Sciences, Faculty of Literature and Humanities, Ilam University, Ilam, Iran
3- Deptt of Physical Education and Sports Sciences, Faculty of Physical education, Kharazmi University, Tehran, Iran
4- Deptt of Physical Education and Sports Sciences, Faculty of Literature and Humanities, Tarbiat Modares University, Tehran, Iran
5- Dept of Medical Basic Sciences, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran , jameie.sb@iums.ac.ir
Abstract:   (3344 Views)
Introduction: Irisin is a myokine that is suggested to be a link between skeletal muscles and other tissues. Simultaneous presence of irisin and glutamate decarboxylase enzyme in purkinje cells of cerebellum led us to examine the potential role of irisin. As glutamate decarboxylase enzyme is responsible for converting glutamate excitatory neurotransmitter to GABA inhibitory neurotransmitters.
 
Materials & Methods: Forty male Wistar rats (weight: 180±20 g) were assigned to five groups as follows: 1) CCI neuropathic pain with swimming training (CCIST); 2) CCI neuropathic pain without swimming training (CCI); 3) No CCI neuropathic pain with swimming training (ST); No CCI neuropathic pain without swimming training (Control); 5) CCI sham surgery (Sham). CCI and CCIST groups underwent peripheral nerve injury by four loose ligatures on the sciatic nerve. The swimming training program included two weeks of swimming (5 sessions per week, 30-60 min per session). The protein expression of irisin in L4-L6 regions was evaluated by western blotting technique.
 
Findings: Irisin expression in the CCIST2 (P=0.039) and ST2 (P=0.016) groups was lower than in the CCI group. However, there was no significant difference between two training groups.
 
Discussion & Conclusions: If we assume a similar role for irisin in the nervous system as in adipose tissue, the lower level of irisin in the two training groups can be justified as it is less needed to reduce ATP production as an excitatory neurotransmitter in the spine.a
Keywords: Irisin, Swimming training, Neuropathic pain, Peripheral nerve injury
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Type of Study: Research | Subject: Physical Education
Received: 2017/10/17 | Accepted: 2017/11/25 | Published: 2018/11/15
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Farzad B, Shamsaei N, Rajabi H, Gharakhanlou R, Jameie S B. Effect of Two-Week Swimming Training on the Expression of Irisin Protein in Lumbar Spine of Rats with Neuropathic Pain . Journal of Ilam University of Medical Sciences 2018; 26 (4) :166-174
URL: http://sjimu.medilam.ac.ir/article-1-4584-en.html


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Volume 26, Issue 4 (11-2018) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
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