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Association of UCP2 45bp ins/del Gene Polymorphism
with Idiopathic Male Infertility
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Arezoo Ghaderi1   , Leila Kohan *  2, Zahra Anvar3 |
1- Dept of Biology, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran
2- Young Researchers and Elite Club, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran , leila_kohan@yahoo.com
3- Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran |
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Abstract: (3843 Views) |
Introduction: Infertility is a reproductive issue that has influenced couples worldwide and caused them psychiatric and emotional troubles. It is believed that mitochondrial proteins play a major role in male infertility. One of the most important of these proteins is UCP2, which consists of more than 10% of mitochondria’s inner membrane proteins. The purpose of this study was to investigate the association of UCP2 45bp ins/del polymorphism with idiopathic male infertility.
Materials & Methods: In this case-control study, UCP2 polymorphism was investigated in 196 individuals with idiopathic infertility and 278 healthy individuals. UCP2 45bp ins/del genotypes were identified by the polymerase chain reaction (PCR) technique. Also, genotype and allele frequencies in cases and controls were assessed by logistic regression analysis.
Findings: No association was observed between UCP2 45bp ins/del polymorphism genotypes and risk of idiopathic male infertility, but there was a marginal difference between cases and controls regarding II genotype frequency (P=0.08). Moreover, data analysis showed that I allele had protective effect against idiopathic male infertility (OR: 0.729, 95%CI: 0.54-0.985, P=0.039).
Discussion & Conclusions: In this study, for the first time, we found that the I allele in UCP2 45bp ins/del polymorphism has protective effects against idiopathic male infertility. Further studies with larger sample sizes and different ethnicities are needed to confirm these results. |
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| Keywords: Idiopathic, Male infertility, UCP2, Polymorphism |
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Full-Text [PDF 852 kb]
(872 Downloads)
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Type of Study: Research |
Received: 2017/06/9 | Accepted: 2017/10/17 | Published: 2019/01/15
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