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:: Volume 26, Issue 5 (1-2019) ::
sjimu 2019, 26(5): 189-195 Back to browse issues page
Association of UCP2 45bp ins/del Gene Polymorphism with Idiopathic Male Infertility
Arezoo Ghaderi1, Leila Kohan 2, Zahra Anvar3
1- Dept of Biology, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran
2- Young Researchers and Elite Club, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran , leila_kohan@yahoo.com
3- Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Abstract:   (495 Views)
Introduction: Infertility is a reproductive issue that has influenced couples worldwide and caused them psychiatric and emotional troubles. It is believed that mitochondrial proteins play a major role in male infertility. One of the most important of these proteins is UCP2, which consists of more than 10% of mitochondria’s inner membrane proteins. The purpose of this study was to investigate the association of UCP2 45bp ins/del polymorphism with idiopathic male infertility.
 
Materials & Methods: In this case-control study, UCP2 polymorphism was investigated in 196 individuals with idiopathic infertility and 278 healthy individuals. UCP2 45bp ins/del genotypes were identified by the polymerase chain reaction (PCR) technique. Also, genotype and allele frequencies in cases and controls were assessed by logistic regression analysis.
Findings: No association was observed between UCP2 45bp ins/del polymorphism genotypes and risk of idiopathic male infertility, but there was a marginal difference between cases and controls regarding II genotype frequency (P=0.08). Moreover, data analysis showed that I allele had protective effect against idiopathic male infertility (OR: 0.729, 95%CI: 0.54-0.985, P=0.039).
 
Discussion & Conclusions: In this study, for the first time, we found that the I allele in UCP2 45bp ins/del polymorphism has protective effects against idiopathic male infertility. Further studies with larger sample sizes and different ethnicities are needed to confirm these results.  
Keywords: Idiopathic, Male infertility, UCP2, Polymorphism
Full-Text [PDF 852 kb]   (144 Downloads)    
Type of Study: Research |
Received: 2017/06/9 | Accepted: 2017/10/17
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Ghaderi A, Kohan L, Anvar Z. Association of UCP2 45bp ins/del Gene Polymorphism with Idiopathic Male Infertility . sjimu. 2019; 26 (5) :189-195
URL: http://sjimu.medilam.ac.ir/article-1-4369-en.html


Volume 26, Issue 5 (1-2019) Back to browse issues page
مجله علمی پزوهشی دانشگاه علوم پزشکی ایلام scientific journal of ilam university of medical sciences
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