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:: Volume 25, Issue 4 (11-2017) ::
Journal of Ilam University of Medical Sciences 2017, 25(4): 34-42 Back to browse issues page
Study of Histological and Histometrical Changes of the Placenta after Administration of Milfoil (Achillea wilhemsii) Hydroalcholic Extract in Rat
Hassan Morovvati *1, Salman Soltani2, Hossein Najafzadeh Varzi3, Ali Loui Monfared4
1- Dept of Basic Sciences, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran , hmorovvati@ut.ac.ir
2- Dept of Basic Sciences, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran
3- Dept of Basic Sciences, Faculty of ParaVeterinary Medicine, Ilam University, Ilam, Iran
4- Ilam university
Abstract:   (4045 Views)

Introduction: Achillea (Asteraceae) is a plant that in recent years its anti-oxidant, anti-inflammatory, anti-spasmodic and anti-microbial qualities have been reported. Its extracts can also be used as a male contraceptive combination that has reversible effects too. The aim of this study is to examine the effects of the extract of this plant on the placenta and fertility.
 
Materials & methods: In this study, 40 female pregnant wistar rats were randomly placed in four equal groups which included one control and three experimental groups. Control group animals were treated with distilled water over 6-16 days. The experimental groups received Achillea plant extract in 200, 400, and 600 mg/kg concentration in the same timetable. Tissue specimens were collected then stained with H&E method and studied under light microscopy.
 
Findings: Results showed that the 400 and 600 mg/kg Achillea extract lead to sever placental congestion, elevation in the thickness of spongium of placenta, an increase in the number of the glycogenic cells and giant cells, elevation in the thickness of LIM of placenta as well as desidual thickness. Anatomical results showed a significant increase in the placental weight, diameter, thickness, index and a significant decrease in the fetal weight and length in treated animals that received the 400 and 600 mg/kg plant extract, compared with the treated animals which received 200 mg/kg plant extract.
 
Discussion & conclusions: According to result of this study, the injection of 400 and 600 mg/kg Achillea extracts leads to histological and histomorphometrical changes in the placenta tissue.
 

Keywords: Achillea, Histomorphometry, Placenta, Rat
Full-Text [PDF 3210 kb]   (1002 Downloads)    
Type of Study: Applicable |
Received: 2016/02/14 | Accepted: 2016/07/20 | Published: 2017/11/1
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Morovvati H, Soltani S, Najafzadeh Varzi H, loui Monfared A. Study of Histological and Histometrical Changes of the Placenta after Administration of Milfoil (Achillea wilhemsii) Hydroalcholic Extract in Rat. Journal of Ilam University of Medical Sciences 2017; 25 (4) :34-42
URL: http://sjimu.medilam.ac.ir/article-1-3387-en.html


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Volume 25, Issue 4 (11-2017) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
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