Introduction: Diabetes is a chronic disease with changes in micro-nutrients, including decrease of magnesium levels, increase of inflammation and impair of lipid metabolism. The aim of this study was to investigate the effect of magnesium on the lipid profile, blood sugar and inflammation in patients with diabetes type 2.

Materials & methods: This interventional study was performed on 40 patients with type II diabetes (16 men and 24 women). Cases were divided randomly into two groups: treatment group 200 mg magnesium daily for a month and control group placebo received. Immediately before and after the treatment period blood samples were taken to determine the FBS, Hb_A1C, magnesium and lipid profile.

Findings: In this study, there was a negative correlation between serum levels of magnesium and CRP. Also an inverse relationship between magnesium and serum levels of HbA1c were observed. In treatment group mean of glucose (FBS) and glycosylated hemoglobin (Hb_A1C) both decreased significantly (p<0.001). In treatment group serum TG and LDL decreased significantly (p<0.05) and HDL levels increased (p<0.001).

Discussion & conclusions: The results showed that oral administration of magnesium in patients with diabetes type II reduces inflammation, improves lipid profile and regulates blood sugar. It seems that oral magnesium intake for a month can be effective in correcting the lipid profile of patients with type II diabetes.