Introduction: Sugarcane is a giant plant of grain products. Regarding the beneficial usages of medications with herbal origin, in the present study, the impact of sugarcane´s hydro alcoholic extract on Cholesterol, Triglyceride, LDL-c and HDL-c in the serum of rabbits with hypercholesterolemia was studied.
Materials & Methods: 24 adult male rabbits in New Zealand race with an average weight of 2 kg were classified into four groups: the control group had a normal diet (6=n), Sham group and the 1,2 experimental groups took a high cholesterol regime(2%). They received drug solvent and sugarcane´s extract with 3.7 and 7.4 mg/kg doses as an oral treatment per day, respectively. After eight weeks, blood samples were taken, and the rate of cholesterol, LDL-c, HDL-c and triglyceride were measured. The obtained results were analyzed using SPSS and ANOVA.
Findings: The results of the survey showed that in treatment with doses 3.7 and 7.4 mg/kg per day of sugarcane´s extract (experimental groups 1 and 2, respectively), a significant reduction (P<0.05, P<0.01 respectively) in the rate of Cholesterol, Triglyceride and LDL-c, and a significant increase (p<0.05, P<0.01 respectively) in HDL-c were occurred in compare with Sham group.
Discussion & Conclusion: Sugarcane´s extract may be effective in reducing the amount of Cholesterol, Triglyceride, and LDL-c and increasing HDL-c.