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Effect of nitric oxide inhibition on weight changes and histology of renal in pregnant rats.
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Mh Nori mogohi *   1, M Khanzad , T Rastegar |
| 1- , noorimoo@sina.tums.ac.ir |
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Abstract: (46607 Views) |
| Introduction: According to the important role of Nitric oxide (NO) in many biological processes in cells and tissues, in this study we examined the inhibitory effects of L-NAME on weight and histology of a pregnant rat kidney.
Materials and Methods: 24 Wistar rats weighing 200- 250 gr with a mean age of 8 weeks upon observing vaginal plaque that has been considered as day zero of pregnancy were divided in 3 groups of 8. Except the control group the remaining groups received normal saline (1mg/kg/ip), L-NAME (1 mg/kg/ip) during 3, 4 and 5th days of pregnancy. On the 18th day of pregnancy the rats were anesthetized by ether and via laparotomy the kidneys were removed. Kidneys fixed in 10% formalin and after tissue sample preparation, general (H + E) staining was performed. Finally the Histomorphological changes were studied by light microscopy.
Findings:Despite the increasing in weight of the L-NAME group, There was no significant differences between groups (P<0.01) but in L-NAME group were observed disorder of the cortex and capsule of a kidney, immune cell infiltration, and congestion blood vessels.
Discussion &Conclusion: Results of this study showed that L-NAME in pregnancy can cause damage in kidney tissue via decreasing levels of NO.
Keywords: Kidney, Nitric oxide, L-NAME |
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| Keywords: Kidney, Nitric oxide, L-NAME |
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Full-Text [PDF 593 kb]
(2831 Downloads)
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Type of Study: Research |
Subject:
anatomy
Received: 2013/07/21 | Accepted: 2013/12/25 | Published: 2014/04/30
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