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Evaluation of Serum Zinc And Copper Levels in PatientsSuffering from Left Anterior Descending Obstruction
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Bahram Yaghmai *   , Faraj allah Maleki |
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Abstract: (15927 Views) |
| Introduction: Atherosclerosis is one of the main causes of mortality in developed countries. Many researchers, in the past, have proved that factors such as: smoking, high blood cholesterol level and high blood pressure play a major role in pathogenesis of cardiovascular diseases. Investigations to find the etiology of the disease have supported the idea that the trace elements may play a role in initiation or progress of atherosclerosis. It has been proved that the trace elements have an essential role in most aspects of metabolism in the body, but still the relationship between the variation of these trace elements with some diseases such as atherosclerosis has not been proved. Therefore, the present study was designed to evaluate the serum copper and zinc levels in patients with obstruction of one of the coroner vessels named LAD (Left Anterior Descending) against the control group.
Materials and methods: In this study, 247 subjects, patients and healthy (control) who have referred to Shahid Modaress hospital, Tehran, were evaluated, including 64 people as the control group (27 female and 37 male) with mean age of 50.88±9.4 years and 183 people as the test group (59 female and 124 male) with mean age of 57.66±9.7 years. According to the results of angiography, there was no sign of obstruction in the control group, but in the test group, there were LAD obstructions. The test and control groups were compared for background and confidence variables. The measurement of trace elements was performed by means of Atomic Absorption Spectrophotometer. The results were calculated by software of SPSS ver. 10.0 and Chi Square and ANOVA statical tests.
Findings: Mean value and standard deviation of serum copper and zinc were studied in both the test and control groups. Mean value of serum copper level in the test group was 0.98±0.25 ppm which in comparison with the mean value of the control group, 0.90±0.27 ppm was higher a difference which was significant (P<0.05). Mean value of serum zinc level in the test group was 0.63±0.22 ppm which in comparison with the mean value of the control group, 0.65±0.20 ppm was lower a difference which was not significant (p>0.05).
Conclusion: According to the results of this and the previous studies, it is important to maintain the normal levels of plasma copper and zinc in the serum since their abnormal levels in the serum may increase the risk of atherosclerosis. |
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| Keywords: atherosclerosis, copper, zinc, LAD |
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Full-Text [PDF 271 kb]
(3746 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2009/07/19 | Accepted: 2015/04/20 | Published: 2015/04/20
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