Comparison of the Genetic Profile of rs4646994 Single Nucleotide Polymorphism of the ACE Gene in the Elite Male Weightlifters and Non-athletes

Mousavi, Seyyed Rasoul; Batavani, Mohammadreza; Ghofrani, Mohsen

doi:10.52547/sjimu.29.4.93

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Volume 29, Issue 4 (10-2021)

Journal of Ilam University of Medical Sciences 2021, 29(4): 93-102

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Comparison of the Genetic Profile of rs4646994 Single Nucleotide Polymorphism of the ACE Gene in the Elite Male Weightlifters and Non-athletes

Seyyed Rasoul Mousavi ^*

¹, Mohammadreza Batavani²

, Mohsen Ghofrani³

1- MSc of Exercise Physiology, Department of Physical Education and Sport Science, Sistan and Baluchestan University, Sistan and Baluchestan, Iran , mousavi.rasoul1400@gmail.com
2- Assistant Professor ,Center of Physical Education, Isfahan University of Technology, Isfahan 84156-83111, Iran
3- Associate Professor, Department of Physical Education and Sport Sciences, Faculty of Physical Education and Sport Sciences, University of Sistan and Baluchestan, Sistan and Baluchestan, Iran

Abstract: (1472 Views)

Introduction: The ACE gene encodes the angiotensin-converting enzyme (ACE), which is characterized by the presence of allele I or the absence of allele D of a 287-bp fragment. The D allele is associated with higher ACE activity and increased angiotensin II levels and performance in strength-oriented exercise tasks. This study aimed to compare the genetic profile of rs4646994 single nucleotide polymorphism of the ACE gene in the elite male weightlifters and non-athletes.
Material & Methods: In total, 30 elite male weightlifters (league, country, national team, Asian, world, and Olympic champions) living in Isfahan province along with 43 healthy non-athlete volunteers who were matched in age, height, and weight to the elite group formed the subjects of the study. After completing the consent form, saliva samples were collected from the participants, and after DNA extraction, ACE genotypes were determined using PCR-RLFP and electrophoresis techniques. Data analysis was performed using independent t-test, chi-square, and logistic regression in SPSS software (version 20).
(Ethic code: 7993)
Findings: The results showed that the prevalence of D allele in elite weightlifters and non-athletes was significantly higher than allele I in their groups (P<0.05). Moreover, in the genotyping distribution, D/I was most common both in the study population (7.50%), as well as weightlifters (7.56%) and non-athletes (5.46%). However, there was no significant difference in the elite weightlifters and non-athletes regarding the distribution of D/I ACE genotyping (χ²=0/31).
Discussion & Conclusion: The study showed a positive relationship between Iranian elite weightlifters and the ACE D allele, which probably distinguishes it as one of the effective genetic factors in creating a strength phenotype of Iranian weightlifters.

Keywords: Allele, Angiotensin-converting enzyme, Elite weightlifters, Mononucleotide polymorphism

Full-Text [PDF 551 kb] (486 Downloads)

Type of Study: Research | Subject: Physical Education
Received: 2021/04/9 | Accepted: 2021/09/1 | Published: 2021/11/1

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‎ 10.52547/sjimu.29.4.93

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Ethics code: 7993

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Mousavi S R, Batavani M, Ghofrani M. Comparison of the Genetic Profile of rs4646994 Single Nucleotide Polymorphism of the ACE Gene in the Elite Male Weightlifters and Non-athletes. J. Ilam Uni. Med. Sci. 2021; 29 (4) :93-102
URL: http://sjimu.medilam.ac.ir/article-1-7055-en.html

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