Introduction: Stretching the shortened structures by stretch exercises is one of the most effective methods for function improvement in patients with patellofemoral pain. Thus, the aim of this study was to compare the effects of proprioceptive neuromuscular facilitation (PNF) and Classic physiotherapy stretching (CPS) exercises on the balance and function in patellofemoral pain patients.
 
Materials & Methods: This was a semi-experimental research in which 33 women with patellofemoral pain syndrome were randomly divided into three PNF (n=11), CPS (n=11) and control (n=11) groups. The PNF group participated in the quadriceps and hamstring PNF for two months, the CPS members participated in the Classic physiotherapy stretching exercisesfor the same period, while the control group did not participate in any exercise program. The function, static as well as dynamic balances were measured by WOMAC scale, Sharpend Romberg test, and SEBT,  respectively. Data were analyzed by ANOVA repeated measures at significance level of 0.05.
 
Findings: As there were  no differences between functions and balances of different groups, (P>0.05) before training interventions, PNF group’s knees functions improved significantly compared to CPS (P<0.01) and control groups, (P=0.003), after the intervention, and also a significant improvement developed in CPS group, compared to the control group, (P=0.014) Furthermore, static and dynamic balance among PNF group patients significantly increased compared to CPS and control groups, (P<0.001). However, no significant difference was observed between CPS and control groups, (P>0.05).
 
Discussion & Conclusions: According to the conclusions of our research, PNF training is more effective in improving function and balance patients with patellofemoral pain; although, classic physiotherapy stretching exercises are often used for the treatment of such patients. Hence, applying  PNF exercises for the treatment of such diseases are recommended to physiotherapists and rehabilitation professionals.