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:: Volume 23, Issue 7 (2-2016) ::
Journal of Ilam University of Medical Sciences 2016, 23(7): 155-163 Back to browse issues page
Studying the Effects of Nanoparticle Cu on Function and Tissue Kidney in Wistar Rat
Abstract:   (5608 Views)

Introduction: Since copper  nanoparticles are one of the first nanoparticles programs in the industry, its adverse effects has increased on humans. The current research  studies the effect of copper nanoparticles on some biomarkers of renal and its tissue.

Materials & methods: A total of 32 Wistar rats were randomly divided into 4 groups: control (treated with .5 cc normal saline) and three experimental groups. Group 1, 2 and 3 received .5 cc of solution containing 10,100,300 ppm Cu nanoparticle via IP injection for 7 successive days, respectively. The effects of nanoparticles Cu on serum biochemical levels serum BUN (blood urea nitrogen), uric acid and ceratinin were evaluated at various time points (1, 7 and 14 days). After 14 days, the tissue kidney was collected and investigated.

Findings: According to the results, the creatinine levels between groups 3, 4 with control group differed significantly in the first week and group 2 with control group , in the second week was observed, respectively. All histological results indicate: complete destruction of the tubules in the renal cortex and destruction renal of renal of corpuscular in the group 2(impact effect of nanoparticle)- slight pathological changes in group 3 and the absence of pathological changes in group 4.

Discussion & Conclusions: According to the results, it can be concluded that the use of copper nanoparticles of spherical shape and 10-15 nm size, slightly was affected on renal factors and sever pathologic changes in the kidney tissue (low dose, 10nm).

Keywords: Nanoparticels Cu, BUN, Renal of corpuscular
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Type of Study: Research | Subject: biology
Received: 2015/01/1 | Accepted: 2015/08/19 | Published: 2016/03/2
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Studying the Effects of Nanoparticle Cu on Function and Tissue Kidney in Wistar Rat. Journal title 2016; 23 (7) :155-163
URL: http://sjimu.medilam.ac.ir/article-1-2420-en.html

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Volume 23, Issue 7 (2-2016) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
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