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Journal of Ilam University of Medical Sciences 2015, 23(1): 127-133 Back to browse issues page
Association of PINK1gene Polymorphism Ala340Thr with Type 2 Diabetes in Sistan and Baluchistan Province
Bashir Ghayori1, Ahmad Rashki *2, Gholam Reza Motaleb3, Mostafa Dahmarde ei3
1- Zabol University
2- Zabol University , ah_rashki@usal.es
3- Zabol university
Abstract:   (7656 Views)

One of the genes that have been recently approvd to be associated with diabetes mellitus type 2 is PINK1. This gene encodes a serine/threonine protein kinase that located in mitochondria. It is thought that it protects cells from stress-induced mitochondrial dysfunction. The aim of the present study was to investigate the association between PINK1 gene polymorphism Ala340Thr with Type 2 diabetes.
 Materials & Methods: In the present case-control study, one hundred patients with type 2 diabetes mellitus and 100 non-diabetic healthy people were selected randomly from the studied population. The PINK1 gene polymorphism (Ala340Thr) was determined using polymerase chain reaction and restriction fragment length polymorphism genotyping assays (PCR- RFLP).
Findings: The frequency of G and A alleles in patient and control groups was 93.5%, 95% and 6.5%, 5% respectively. In this study allele frequency didn´t show any significant difference between patient and control groups. The frequency of GG and GA for PINK1 gene was 87% and 13% in patient group, and 90% and10% in control group respectively
 Discussion & Conclusion: According to the obtained results in this study, there isn´t any significant correlation between Ala340Thr variant of PINK1 with Type 2 diabetes. The Ala340Thr variant could not present as a risk factor for type 2 diabetes.

Keywords: Type 2 diabetes mellitus, RFLP-PCR, Polymorphism, PINK1
Full-Text [PDF 481 kb]   (1901 Downloads)    
Type of Study: Research | Subject: Molecular Genetics
Received: 2014/02/7 | Accepted: 2014/06/10 | Published: 2015/05/18
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Ghayori B, Rashki A, Motaleb G R, Dahmarde ei M. Association of PINK1gene Polymorphism Ala340Thr with Type 2 Diabetes in Sistan and Baluchistan Province. Journal title 2015; 23 (1) :127-133
URL: http://sjimu.medilam.ac.ir/article-1-1569-en.html

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Volume 23, Issue 1 (4-2015) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
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