One of the genes that have been recently approvd to be associated with diabetes mellitus type 2 is PINK1. This gene encodes a serine/threonine protein kinase that located in mitochondria. It is thought that it protects cells from stress-induced mitochondrial dysfunction. The aim of the present study was to investigate the association between PINK1 gene polymorphism Ala340Thr with Type 2 diabetes.
 Materials & Methods: In the present case-control study, one hundred patients with type 2 diabetes mellitus and 100 non-diabetic healthy people were selected randomly from the studied population. The PINK1 gene polymorphism (Ala340Thr) was determined using polymerase chain reaction and restriction fragment length polymorphism genotyping assays (PCR- RFLP).
Findings: The frequency of G and A alleles in patient and control groups was 93.5%, 95% and 6.5%, 5% respectively. In this study allele frequency didn´t show any significant difference between patient and control groups. The frequency of GG and GA for PINK1 gene was 87% and 13% in patient group, and 90% and10% in control group respectively
 Discussion & Conclusion: According to the obtained results in this study, there isn´t any significant correlation between Ala340Thr variant of PINK1 with Type 2 diabetes. The Ala340Thr variant could not present as a risk factor for type 2 diabetes.