[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 17, Issue 1 (4-2009) ::
Journal of Ilam University of Medical Sciences 2009, 17(1): 31-38 Back to browse issues page
Breast Cancer And Glutathione s-transferaseGenetic Polymorphism
Mitra Azizian *, Bahram Yaghmaei
Abstract:   (14678 Views)
Introduction: Breast cancer is one of the most common known cancers among women of all the racial groups. Thus, a study on both the genetic and environmental factors provides a new chance for us to comprehend the risks of breast cancer. Molecular studies were performed in order to elucidate the relationship between three polymorphic metabolic enzymes with breast cancer. Materials & Methods: In this case-control study, the polymorphisms of glutathione s-transferase (GST) M1, T1 and P1 were analyzed by PCR in genomic DNA from blood samples of 31 female breast cancer patients against 46 women as the control group. To investigate any possible relationships between genotype in GSTT1 and GSTM 1 a Mult. PCR method was used, while for genotype in GSTP 1 a PCR-RFLP method was designed and followed. To determine the relationship between genotypes of GSTT1, GSTM1, and GSTP1 with breast-canser risks, the OR (odd ratio) was calculated with a 95 certainty distance. Findings: GSTT1 null genotype was a risk factor (odd ratio (OR), 4.75, 95% confidence interval (CI), 1.66-13.51). Hetrozygoute polymorphism of GSTP1 at nucleotide 313 was associated (OR, 3.85 95% CI, 1.39- 10.61). GSTM1 null genotype was not associated with the breast cancer risk. Discussion & Conclusion: According to the achievements of the study, we conclude that GSTP1 and GSTT1 genes could play a role in carcinogenesis in the breast cancer.
Keywords: breast cancer, glutathione s-transferase, polymorphism
Full-Text [PDF 329 kb]   (3805 Downloads)    
Type of Study: Research | Subject: General
Received: 2009/08/5 | Accepted: 2015/04/20 | Published: 2015/04/20
Add your comments about this article
Your username or Email:


XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

azizian M, yaghmaei B. Breast Cancer And Glutathione s-transferaseGenetic Polymorphism. Journal title 2009; 17 (1) :31-38
URL: http://sjimu.medilam.ac.ir/article-1-104-en.html

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 17, Issue 1 (4-2009) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
Persian site map - English site map - Created in 0.14 seconds with 31 queries by YEKTAWEB 4555