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:: Volume 32, Issue 2 (6-2024) ::
Journal of Ilam University of Medical Sciences 2024, 32(2): 1-16 Back to browse issues page
Impact of exercise training on inflammatory markers in adult and elderly patients with chronic obstructive pulmonary disease: A Systematic review and meta-analysis
Fatemeh Kazeminasab * 1, Nasim Behzanejad2 , Mousa Khalafi3
1- Dept of Physical Education and Sport Sciences/Faculty of Humanities, University of Kashan, Kashan, Iran & Dept of Physical Education and Sport Sciences/Faculty of Humanities, University of Kashan, Kashan, Iran , f_kazemi85@yahoo.com
2- Dept of Exercise Physiology/Faculty of Physical Education and Sport Sciences, University of Isfahan, Isfahan, Iran
3- Dept of Physical Education and Sport Sciences/Faculty of Humanities, University of Kashan, Kashan, Iran
Abstract:   (548 Views)
Introduction:  Chronic obstructive pulmonary disease (COPD) is one of the respiratory diseases in which inflammation plays a key role in its development. Exercise training has acritical role in improving chronic inflammation. Nonetheless, the effects of various exercise training on inflammatory markers in these patients are not clear. Therefore, the present study aimed to assess the impact of exercise on the inflammatory markers, including IL-6, TNF-α, and c-reactive protein in patients with COPD.
Material & Methods: A systematic search was conducted on PubMed, Web of Science, SID, Magiran, and Google scholar databases for articles published until July 2023. A meta-analysis was performed for the impact of exercise on inflammatory markers in COPD patients. Effect size (SMD) and 95% confidence interval were calculated using random effect model. Moreover, I2 test was employed to determine heterogeneity, while Funnel plot test and Egger test were used to check publication bias.
Results: The results of the data analysis of 11 studies on 578 patients with COPD demonstrated that exercise led to a non-significant decrease in circulating CRP values [SMD=-0.413 (-0.100 to 0.175), P=0.16], IL-6 [SMD=-0.164 (-0.69 to 0.36], P=0.54], TNF-α [SMD=-0.358 (-1.44 to 0.72), P=0.51) in COPD patients. Furthermore, the results of the subgroup analysis pointed out that aerobic training [SMD=-0.55, P=0.1] compared to resistance training [SMD=-0.09, P=0.7] led to a decrease in CRP in patients with COPD. Nonetheless, this difference was not significant.
Discussion & Conclusion: The findings of the present meta-analysis illustrated that aerobic exercise is probably an effective exercise intervention to reduce CRP in patients with COPD.
Keywords: Chronic obstructive pulmonary disease, C-reactive protein Exercise, Interleukin 6, Tumor necrosis factor-alpha
Full-Text [PDF 1806 kb]   (274 Downloads)    
Type of Study: Research | Subject: Physical Education
Received: 2023/07/18 | Accepted: 2024/01/8 | Published: 2024/06/4
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Kazeminasab F, Behzanejad N, Khalafi M. Impact of exercise training on inflammatory markers in adult and elderly patients with chronic obstructive pulmonary disease: A Systematic review and meta-analysis. J. Ilam Uni. Med. Sci. 2024; 32 (2) :1-16
URL: http://sjimu.medilam.ac.ir/article-1-8038-en.html
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Volume 32, Issue 2 (6-2024) Back to browse issues page
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