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The Study of Antibiotic Properties of Scrophularia Striata Aqueous Extract on Staphylococcus aureus
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M Zamanian azodi   , Ar Ardashiri lajimi , N Ahmadi * 1, S Gilanchi , N Abbasi , A Hematian |
| 1- , nayebalia@yahoo.com |
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Abstract: (13070 Views) |
| Introduction: Bacteria have become resistant to some kinds of antibiotics. Therefore, more reliable sources are vital to be examined. Some types of herbals have been shown promising for therapeutic points, so they could be applied in the field of medicine. Scrophularia consist of different biological activities such as antimicrobial, antitumor and anti-inflammatory activities. Consequently, its effect on Staphylococcus aureus has been studied.
Material & Methods: Antibiotic effects of both filtered and non-filtered extract of Scrophularia striata on Staphylococcus aureus as gram-positive bacterium were evaluated by spectrophotometer. Simultaneously tetracycline was used as a positive control at different concentrations. In addition, MTT assay was applied for cell survival determination.
Findings: Our findings point out that concentration between 1 to 20 µg/ml of the extract has remarkable antibiotic activities. In addition to this, there is no obvious difference between filtered and non-filtered antibiotic activities of this extract. On the other hand, fibroblast cells show absolutely different response when treated with the same extract.
Discussion & Conclusion: It can be concluded that, the Scrophularia striata aqueous extract has significant antibiotic activity and with less side effects than tetracycline. As a result, Scrophularia striata extract can be regard as a probable antibiotic agent in the future studies additionally, more investigation is needed for evaluating in vivo outcomes, and the effective materials of the extract component |
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| Keywords: Scrophularia striata; Antimicrobial Effects Staphylococcus aureus; Human Fibroblast Cell line, Tetracycline |
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Full-Text [PDF 384 kb]
(3219 Downloads)
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Type of Study: Research |
Subject:
Medical microbiology
Received: 2013/03/17 | Accepted: 2013/05/13 | Published: 2013/05/13
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