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:: Volume 20, Issue 4 (2-2013) ::
Journal of Ilam University of Medical Sciences 2013, 20(4): 127-133 Back to browse issues page
Study of Antibiotical Effects of Scrophularia Striata With Tetracyclin Aqueous Extract on E. Coli in Comparison With Tetracyclin
M Zamaninan Azodi, Ar Ardeshiry Lajimi, M, Rezaei Tavirani, M, Rezaei Tavirani *1, R Khodarahmi
1- , tavirani_m@yahoo.com
Abstract:   (20181 Views)
Introduction: Since bacteria became resistant to some types of antibiotics, it is prominent to find more reliable sources against them. In view of the fact that plants have been shown verity of biological eff-ects, they could be promising substitutions. Inasmuch as Scrophularia has shown differ-rent biological properties such as antimic-robial, antitumor and anti-inflammatory activities, its effect on Escherichia coli has been evaluated. Material & Methods: Antibiotic effects of both filtered and nonfiltered extract of Scro-phularia striata on Escherichia coli as gram-negative bacterium were evaluated by spectrophotometery method. Simultaneou-sly tetracycline was used as a positive control at different concentrations. In addi-tion, MTT assay was applied for cell surv-ival determination. Findings: Our findings indicate that conc-entrations between 1 to 20 µg/ml of the extract have significant antibiotic activities there is no noticeable difference between filtered and nonfiltered antibiotic activities of this extract. Moreover, this effect is totally different from inducing properties of the extract. Discussion & Conclusion: In conclusion, 5 µg/ml of the extract has a significant antibiotic activity whereas there is not such an effect on fibroblast cells. In view of the fact that this concentration of the extract has a potential antibiotic activity accomp-anied with considerable low side effects on human cells, Scrophularia striata extract can be regard as a potential antibiotic agent in the future.
Keywords: scrophularia striata; antim-icrobial effects; escherichia coli; human fibroblast cell line
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Type of Study: case report | Subject: Microbiology
Received: 2013/02/24 | Accepted: 2013/03/17 | Published: 2013/03/17
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Zamaninan Azodi M, Ardeshiry Lajimi A, , Rezaei Tavirani M, , Rezaei Tavirani M, Khodarahmi R. Study of Antibiotical Effects of Scrophularia Striata With Tetracyclin Aqueous Extract on E. Coli in Comparison With Tetracyclin. Journal of Ilam University of Medical Sciences 2013; 20 (4) :127-133
URL: http://sjimu.medilam.ac.ir/article-1-883-en.html


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Volume 20, Issue 4 (2-2013) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
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