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:: Volume 32, Issue 1 (4-2024) ::
Journal of Ilam University of Medical Sciences 2024, 32(1): 83-98 Back to browse issues page
Fabrication and Characterization of Nanofibrous Wound Dressings Containing Gentamicin-conjugated Nanoclay
Hadi Samadian1 , Mahnaz Mohammadpour2 , Soheila Zare3 , Zhila Izadi4 , Sajad Moradi5 , Hashem Moradi3 , Hossein Derakhshankhah * 6
1- Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
2- Dept of chemistry, Faculty of Sciences, Tarbiat Modares University, Tehran, Iran
3- Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
4- Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
5- Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
6- Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran , derakhshankhah.hossein@gmail.com
Abstract:   (344 Views)
Introduction:  The development of bioactive wound dressings with high healing efficacy is one of the most important domains in interdisciplinary fields. The objective of the present study was to fabricate and characterize a nanofibrous wound dressing containing gentamicin-conjugated nanoclay.
Material & Methods: First, the interaction between the structure of nanoclays and gentamicin was evaluated based on computer simulation methods and using Gaussian software. Then, the purified nanoclays were conjugated with gentamicin, and the properties of the resulting nanoparticles were analyzed. The synthesized nanocomplex was integrated into the nanofiber structure using the electrospinning method, and the nanofiber wound covering was identified. Finally, the biological properties of nanofiber wound dressing were investigated.
Results: Numerical studies indicated that there were negatively charged oxygen groups on both sides of the nanoclay plates, which could make stable interactions with the positively charged nitrogen in gentamicin, and the drug was well-loaded between pages. The characterization results demonstrated that nanofiber wound dressings had acceptable characteristics in terms of morphology, diameter, wettability, mechanical properties, swelling, and bacterial penetration barrier. These functions provide a suitable environment for wound healing. The addition of gentamicin led to beneficial biological properties for prepared wound dressings, and these nanofibers had acceptable hemocompatibility and biocompatibility.
Discussion & Conclusion: The findings of the present research can be a fundamental step for using the combination of kaolin/polyvinyl alcohol nanofibers containing gentamicin in various fields of pharmaceutical bioengineering, including the production of wound dressings.
Keywords: Nanofiber wound dressing, Gentamycin, Polyvinyl alcohol (PVA), Kaolin, Nanoclay, Gossin
Full-Text [PDF 713 kb]   (109 Downloads)    
Type of Study: Research | Subject: pharmacology
Received: 2023/12/31 | Accepted: 2024/03/4 | Published: 2024/05/4
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Samadian H, Mohammadpour M, Zare S, Izadi Z, Moradi S, Moradi H et al . Fabrication and Characterization of Nanofibrous Wound Dressings Containing Gentamicin-conjugated Nanoclay. J. Ilam Uni. Med. Sci. 2024; 32 (1) :83-98
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Volume 32, Issue 1 (4-2024) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
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