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:: Volume 32, Issue 2 (6-2024) ::
Journal of Ilam University of Medical Sciences 2024, 32(2): 44-54 Back to browse issues page
Effect of aerobic training and capsaicin on the expression of lipogenic genes SREBP-1c and FASN in liver tissue of obese rats
Fatemeh Ghoreishi1 , Saqqa Farajtabar Behrestaq * 2, Amir Taghipoor asrami1 , Masoumeh Habibian1
1- Dept of Physical Education and Sport Sciences, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran & Dept of Physical Education and Sport Sciences, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran
2- Dept of Physical Education and Sport Sciences, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran & Dept of Physical Education and Sport Sciences, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran , farajtabarp@yahoo.com
Abstract:   (141 Views)
Introduction:  Consuming a high-fat diet causes obesity, which is one of the hallmarks of metabolic syndrome. The present study aimed to assess the effect of aerobic training and capsaicin supplementation on the expression of lipogenic genes SREBP-1c and FASN in the liver tissue of obese rats
Material & Methods:  For this experimental research, 40 eight-week-old male Wistar rats weighing 181.5±2.3 grams were selected as samples. Thereafter, eight rats were fed a normal diet (ND), and 32 rats were fed a high-fat diet (HFD) and randomly assigned to five groups: normal diet, high-fat diet, high-fat diet-training, high-fat diet-capsaicin, and high-fat diet-training-capsaicin. The exercise groups performed an incremental aerobic exercise program (15-25 m/min, 30-60 min/day, five days/week) on a treadmill for eight weeks. Capsaicin (4 mg/kg/day) was taken orally by gavage once a day.
Results: Induction of obesity was associated with increased expression of SREBP-1C (P=0.001) and FASN (P=0.001). It was also revealed that aerobic exercise with capsaicin supplementation significantly decreased SREBP-1C and FASN gene expression in the experimental groups compared to the obese group. Finally, this reduction trend was significant in the combined group compared to the supplement group.
Discussion & Conclusion: It is possible that the use of capsaicin, along with aerobic physical activity, is an effective strategy to neutralize the markers of hepatic lipogenesis.
Keywords: Aerobic exercise, Capsaicin, FASN, Liver, SREBP-1c
Full-Text [PDF 1332 kb]   (89 Downloads)    
Type of Study: Research | Subject: Physical Education
Received: 2023/10/29 | Accepted: 2024/04/16 | Published: 2024/06/4
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Ghoreishi F, Farajtabar Behrestaq S, Taghipoor asrami A, Habibian M. Effect of aerobic training and capsaicin on the expression of lipogenic genes SREBP-1c and FASN in liver tissue of obese rats. J. Ilam Uni. Med. Sci. 2024; 32 (2) :44-54
URL: http://sjimu.medilam.ac.ir/article-1-8131-en.html


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Volume 32, Issue 2 (6-2024) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
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