[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
Publication Ethics::
Peer Review Process::
Indexing Databases::
For Authors::
For Reviewers::
Subscription::
Contact us::
Site Facilities::
::
Google Scholar Metrics

Citation Indices from GS

AllSince 2019
Citations64463744
h-index2720
i10-index18983

..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Registered in

AWT IMAGE

AWT IMAGE

..
:: Volume 32, Issue 1 (4-2024) ::
Journal of Ilam University of Medical Sciences 2024, 32(1): 58-65 Back to browse issues page
Serological study of the frequency of human herpesvirus-8 in patients with liver cirrhosis
Ava Hashempour1 , Zahra Musavi1 , Javad Moayedi * 2
1- HIV/AIDS Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran
2- HIV/AIDS Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran , cbrc@sums.ac.ir
Abstract:   (156 Views)
Introduction:  Various factors, including viruses, are involved in developing liver cirrhosis. Although the association of human herpesvirus-8 (HHV-8) with liver cirrhosis remains poorly understood, a significant increase in the titer of antibodies against this virus has been observed in cirrhotic patients. The present study aimed to evaluate the frequency of HHV-8-immunoglobulin G (HHV-8 IgG) in Iranian patients with liver cirrhosis.
Material & Methods: In this cross-sectional study, 30 healthy blood donors and 30 patients with liver cirrhosis related to hepatitis B (n=20) and hepatitis C (n=10) viruses from those waiting for liver transplantation were included. The serum seropositivity of HHV-8 IgG antibody was evaluated using the enzyme-linked immunosorbent assay (ELISA) technique.
Results: The seropositivity of HHV-8 IgG antibodies in patients and healthy groups was 6.7% (2 patients) and 3.3% (1 case), respectively, which did not show a significant difference between the two groups (P=0.554). In addition, the infection was not significantly related to the age and gender of the patients (P>0.05).
Discussion & Conclusion: Considering the low prevalence of HHV-8 infection in Iranian patients with liver cirrhosis, it can be concluded that HHV-8 may not be associated with the incidence and progression of liver cirrhosis. Therefore, HHV-8 monitoring will not raise the concern about the development or worsening of liver disorders.
Keywords: CMV infection, Kidney transplantation, Rejection
Full-Text [PDF 390 kb]   (98 Downloads)    
Type of Study: Research | Subject: gastrointestinal and hepatic
Received: 2023/10/16 | Accepted: 2023/12/11 | Published: 2024/05/4
References
1. Rohner E, Wyss N, Trelle S, Mbulaiteye SM, Egger M, Novak U, et al. HHV-8 seroprevalence: a global view. Syst Rev 2014; 3:11-18. doi: 10.1186/2046-4053-3-11.
2. Tseng KC, Lin MN, Chu TY, Tsai JP, Su CC. Predictors of seropositivity for human herpesvirus type 8 in patients with mild cirrhosis. Emerg Microbes Infect 2017;6: e45. doi: 10.1038/emi.2017.32.
3. Noaimi AA, Hameedi AD, Abdullah MM, Ibrahim GA, Hassan HG. Association of Human Herpesvirus Type 8 (HHV-8) expression in patients with Kaposi’s sarcoma: A clinico-immunohistochemical study. J Pak Assoc Dermatol 2023; 33:1446-53.
4. Balada E, Ramentol M, Felip L, Ordi-Ros J, Selva-O'Callaghan A, Simeon-Aznar CP, et al. Prevalence of HHV-8 in systemic autoimmune diseases. J Clin Virol 2015; 62:84-88. doi: 10.1016/j.jcv.2014.11.022.
5. Zhang T, He N, Ding Y, Crabtree K, Minhas V, Wood C. Prevalence of human herpesvirus 8 and hepatitis C virus in a rural community with a high risk for blood-borne infections in central China. Clin Microbiol Infect 2011; 17:395-401. doi: 10.1111/j.1469-0691.2010. 03287.x.
6. Zghair AN, Kasim SF, Mohammed NS, Sharma AK. Seroprevalence and Biomarkers Detection of Human Herpes Virus (HHV-8) in Patients with Kaposi Sarcoma. J Tech 2023; 5:141-46. doi: 10.51173/jt. v5i2.857.
7. Jalilvand S, Shoja Z, Mokhtari-Azad T, Nategh R, Gharehbaghian A. Seroprevalence of Human herpesvirus 8 (HHV-8) and incidence of Kaposi's sarcoma in Iran. Infect Agent Cancer 2011; 6:1-6. doi: 10.1186/1750-9378-6-5.
8. Gras J, Helary M, Carette D, Minier M, Salmona M, Gabassi A, et al. Prevalence, Risk Factors, and Shedding of Human Herpes Virus-8 Among Men Having Sex with Men Enrolled in a Pre-Exposure Prophylaxis Study. Clin Infect Dis 2023; 502:1-7. doi: 10.1093/cid/ciad502.
9. Tung YC, Ke LY, Tsai SM, Lu PL, Tsai WC. High seroprevalence of human herpesvirus 8 infection in patients with systemic lupus erythematosus. Int J Rheum Dis 2013; 16:709-14. doi: 10.1111/1756-185X.12193.
10. Atamna A, Yahav D, Hirzel C. Prevention of Oncogenic Gammaherpesvirinae (EBV and HHV8) Associated Disease in Solid Organ Transplant Recipients. Transpl Int 2023; 36:1-12. doi: 10.3389/ti.2023.11856.
11. Ferrarese A, Zanetto A, Gambato M, Bortoluzzi I, Nadal E, Germani G, et al. Liver transplantation for viral hepatitis in 2015. World J Gastroenterol 2016; 22:1570-80. doi: 10.3748/wjg. v22.i4.1570.
12. Welker MW, Zeuzem S. Pre-and post-transplant antiviral therapy (HBV, HCV). Visc Med 2016; 32:105-09. doi: 10.1159/000445152.
13. Alborzi A, Hashempour T, Moayedi J, Musavi Z, Pouladfar G, Merat S. Role of serum level and genetic variation of IL-28B in interferon responsiveness and advanced liver disease in chronic hepatitis C patients. Med Microbiol Immunol 2017; 206:165-74. doi: 10.1007/s00430-017-0497-y.
14. Hashempoor T, Alborzi AM, Moayedi J, Ajorloo M, Bamdad T, Sharifi AH, et al. A Decline in Anti-Core+ 1 Antibody Titer Occurs in Successful Treatment of Patients Infected with Hepatitis C Virus. Jundishapur J Microbiol 2018;11: e58294. doi: 10.5812/jjm.58294.
15. Chou A, Huang W, Lin M, Su C. Human herpesvirus type 8 in patients with cirrhosis independent of thrombocytopenia. J Clin Pathol 2010; 63:254-58. doi: 10.1136/jcp.2009.071621.
16. Martini S, Tandoi F, Romagnoli R, Rizzetto M. Liver transplantation in hepatitis B/hepatitis D (delta) virus coinfected recipients. Transplantation 2022; 106:1935-39. doi: 10.1097/TP.0000000000004138.
17. Mahmud S, Akbarzadeh V, Abu-Raddad LJ. The epidemiology of hepatitis C virus in Iran: Systematic review and meta-analyses. Sci Rep 2018; 8:150. doi: 10.1038/s41598-017-18296-9.
18. Merat S, Malekzadeh R, Rezvan H, Khatibian M. Hepatitis B in Iran. Arch Iran Med 2000; 3:192-201.
19. Sarvari J, Mansouri M, Hashempoor T, Hosseini SY, Moattari A, Pirbonyeh N, et al. Association of genotype and haplotype of IL-28B Gene with Hepatitis C infection outcome in iran: Spontaneous clearance versus chronic infection. Hepat Mon 2017;17: e45745. doi: 10.5812/hepatmon.45745.
20. Salehi-Vaziri M, Sadeghi F, Almasi Hashiani A, Gholami Fesharaki M, Alavian SM. Hepatitis B Virus Infection in the General Population of Iran: An Updated Systematic Review and Meta-Analysis. Hepat Mon 2016;16: e35577. doi: 10.5812/hepatmon.35577.
21. Hladik W, Dollard SC, Mermin J, Fowlkes AL, Downing R, Amin MM, et al. Transmission of human herpesvirus 8 by blood transfusion. N Engl J Med 2006; 355:1331-38. doi: 10.1056/NEJMoa055009.
22. Zavitsanou A, Sypsa V, Petrodaskalaki M, Kalapothaki V, Whitby D, Hatzakis A. Human herpesvirus 8 (HHV‐8) infection in healthy urban employees from Greece: Seroprevalence and associated factors. J Med Virol 2007; 79:591-96. doi: 10.1002/jmv.20812.
23. Chou AL, Huang WW, Tsao SM, Li CT, Su CC. Human herpesvirus type 8 in patients with cirrhosis: correlation with sex, alcoholism, hepatitis B virus, disease severity, and thrombocytopenia. Am J Clin Pathol 2008; 130:231-37. doi: 10.1309/4FMBN316N4792UQ4.
24. Su CC, Tseng KC, Lin MN, Hsieh TC, Chu TY. High seroprevalence of human herpesvirus type 8 in patients with hepatocellular carcinoma. Eur J Clin Microbiol Infect Dis 2015; 34:55-62. doi: 10.1007/s10096-014-2206-8.
25. Wang W, Gehris BT, Mai B, Chen L, Hu S, You MJ, et al. HHV8-Negative Effusion-Based lymphoma in a patient with recurrent HCV hepatitis status post liver transplantation. Leuk Lymphoma 2022; 63:3480-83. doi: 10.1080/10428194.2022.2123233.
26. Ozaki Y, Tajiri H, Tanaka-Taya K, Mushiake S, Kimoto A, Yamanishi K, et al. Frequent detection of the human herpesvirus 6-specific genomes in the livers of children with various liver diseases. J Clin Microbiol 2001; 39:2173-77. doi: 10.1128/jcm.39.6.2173-2177.2001.
27. Li JC. Reactivation of human herpesvirus (HHV) 6 as etiology of acute liver injury in drug reaction with eosinophilia and systemic symptoms (dress) syndrome: a case report. Cureus 2022; 14:1-7. doi: 10.7759/cureus.29697.
28. Khademolhosseini F, Malekhosseini S, Salahi H, Nikeghbalian S, Bahador A, Lankarani KB, et al. Outcome and characteristics of patients on the liver transplant waiting list: Shiraz experience. Middle East J Dig Dis 2009; 1:63-67.
29. Cohen GM, Langer AL, Sima H, Chang C, Troy K, Taimur S. Hemophagocytic lymphohistiocytosis due to primary HHV-8 infection in a liver transplant recipient. Transplant Direct 2018; 4:411-14. doi: 10.1097/TXD.0000000000000850.
30. Hashempour A, Moayedi J, Musavi Z, Ghasabi F, Halaji M, Hasanshahi Z, et al. First report of HHV-8 viral load and seroprevalence of major blood-borne viruses in Iranian patients with systemic sclerosis. Mult Scler Relat Disord 2021; 51:102872. doi: 10.1016/j.msard.2021.102872.
31. Light TP, Brun D, Guardado-Calvo P, Pederzoli R, Haouz A, Neipel F, et al. Human herpesvirus 8 molecular mimicry of ephrin ligands facilitates cell entry and triggers EphA2 signaling. PLoS Biol 2021;19: e3001392. doi: 10.1371/journal.pbio.3001392.
32. Liu CY, Chen BJ, Chuang SS. Primary effusion lymphoma: a timely review on the association with HIV, HHV8, and EBV. Diagnostics 2022; 12:713-31. doi: 10.3390/diagnostics12030713.
33. Meidani M, Aminzadeh Z, Faghih M, Ahmadi N. Are the preventive services for HHV-8 necessary in HIV positive persons in central zone of Iran? Iran J Pathol 2014; 9:133-37.
34. Gharehbaghian A, Zaghal A, Farhadi Langerudi M, Karimi G. Seroepidemiology of the human Herpesvirus (HHV-8) in the haemodialysis patients’ blood donors and HIV-positive individuals in City of Tehran. J Sch Public Health Inst Public Health Res 2006; 4:57-63.
35. Copeland MMM, Trainor J, Cash WJ, Braniff C. Fatal donor-derived Kaposi sarcoma following liver transplantation. BMJ Case Rep 2021;14: e236061. doi: 10.1136/bcr-2020-236061.
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA

Ethics code: IR.SUMS.REC.1397.772


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Hashempour A, Musavi Z, Moayedi J. Serological study of the frequency of human herpesvirus-8 in patients with liver cirrhosis. J. Ilam Uni. Med. Sci. 2024; 32 (1) :58-65
URL: http://sjimu.medilam.ac.ir/article-1-8123-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 32, Issue 1 (4-2024) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
Persian site map - English site map - Created in 0.15 seconds with 41 queries by YEKTAWEB 4654