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:: Volume 32, Issue 1 (5-2024) ::
Journal of Ilam University of Medical Sciences 2024, 32(1): 58-65 Back to browse issues page
Serological study of the frequency of human herpesvirus-8 in patients with liver cirrhosis
Ava Hashempour1 , Zahra Musavi1 , Javad Moayedi * 2
1- HIV/AIDS Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran
2- HIV/AIDS Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran , cbrc@sums.ac.ir
Abstract:   (92 Views)
Introduction:  Various factors, including viruses, are involved in developing liver cirrhosis. Although the association of human herpesvirus-8 (HHV-8) with liver cirrhosis remains poorly understood, a significant increase in the titer of antibodies against this virus has been observed in cirrhotic patients. The present study aimed to evaluate the frequency of HHV-8-immunoglobulin G (HHV-8 IgG) in Iranian patients with liver cirrhosis.
Material & Methods: In this cross-sectional study, 30 healthy blood donors and 30 patients with liver cirrhosis related to hepatitis B (n=20) and hepatitis C (n=10) viruses from those waiting for liver transplantation were included. The serum seropositivity of HHV-8 IgG antibody was evaluated using the enzyme-linked immunosorbent assay (ELISA) technique.
Results: The seropositivity of HHV-8 IgG antibodies in patients and healthy groups was 6.7% (2 patients) and 3.3% (1 case), respectively, which did not show a significant difference between the two groups (P=0.554). In addition, the infection was not significantly related to the age and gender of the patients (P>0.05).
Discussion & Conclusion: Considering the low prevalence of HHV-8 infection in Iranian patients with liver cirrhosis, it can be concluded that HHV-8 may not be associated with the incidence and progression of liver cirrhosis. Therefore, HHV-8 monitoring will not raise the concern about the development or worsening of liver disorders.
Keywords: CMV infection, Kidney transplantation, Rejection
Full-Text [PDF 390 kb]   (57 Downloads)    
Type of Study: Research | Subject: gastrointestinal and hepatic
Received: 2023/10/16 | Accepted: 2023/12/11 | Published: 2024/05/4
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Hashempour A, Musavi Z, Moayedi J. Serological study of the frequency of human herpesvirus-8 in patients with liver cirrhosis. J. Ilam Uni. Med. Sci. 2024; 32 (1) :58-65
URL: http://sjimu.medilam.ac.ir/article-1-8123-en.html
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Volume 32, Issue 1 (5-2024) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
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