[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Journal Information::
Articles archive::
Publication Ethics::
Peer Review Process::
Indexing Databases::
For Authors::
For Reviewers::
Contact us::
Site Facilities::
Google Scholar Metrics

Citation Indices from GS

AllSince 2019

Search in website

Advanced Search
Receive site information
Enter your Email in the following box to receive the site news and information.
Registered in



:: Volume 16, Issue 3 (10-2008) ::
Journal of Ilam University of Medical Sciences 2008, 16(3): 1-9 Back to browse issues page
Effects of Aluminum on Cultured Human Embryonic Astrocytes and Apoptotic Gene Expression
Abstract:   (12392 Views)
Abstract Introduction: Aluminum is the third most abundant element in the earth's crust .It plays a role in several neurodegenerative conditions including Alzheimer's disease. In this study, we investigated the effects of aluminum on human embryonic astrocytes. Materials & methods: In this experimental study, we applied MTT techniques to investigate the effects of 3,9, and 12 days exposure to aluminum on astrocyte viability . Then, we used immunocytochemical techniques to identify apoptotic gene expression changes induced by aluminum. We used Stata software to analyze the data. Findings: Our results showed that 3-days exposure to 1 and 1.5 mM caused a reduction in astrocytes viability, (P<0.01, P<0.03). Low levels of aluminum (500 and 100 µM) needed long-term exposure to become toxic to astrocytes, (9 days for 500 and 12 days for 100 µM) (P=0.000). Aluminum didn't show any effects on apoptotic gene expression. Conclusion: Long-term exposure, even to low levels of aluminum, was toxic for human embryonic astrocytes, but it seems that aluminum does not alter apoptotic gene expression.
Keywords: aluminum, astrocyte, human embryo, cytotoxicity
Full-Text [PDF 346 kb]   (2785 Downloads)    
Type of Study: Research | Subject: General
Received: 2009/02/18 | Accepted: 2015/04/20 | Published: 2015/04/20
Add your comments about this article
Your username or Email:


XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Effects of Aluminum on Cultured Human Embryonic Astrocytes and Apoptotic Gene Expression. J. Ilam Uni. Med. Sci. 2008; 16 (3) :1-9
URL: http://sjimu.medilam.ac.ir/article-1-81-en.html

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 16, Issue 3 (10-2008) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
Persian site map - English site map - Created in 0.15 seconds with 41 queries by YEKTAWEB 4653