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:: Volume 31, Issue 5 (12-2023) ::
Journal of Ilam University of Medical Sciences 2023, 31(5): 85-93 Back to browse issues page
Association of polymorphism rs1859962 with prostate cancer in Iranian men
Zahra Masori1 , Seyed abdolhamid Angaji1 , Gilda Karimi * 2, Behnaz Beikzadeh3 , Raheleh Roudi4
1- Dept of Molecular Cell Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran
2- Dept of Molecular Cell Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran , g.karimi@khu.ac.ir
3- Dept of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
4- Dept of Radiology, Molecular Imaging Program at Stanford, Stanford University, Stanford, CA94305, USA
Abstract:   (419 Views)
Introduction: One of the most common malignancies in men is prostate cancer. According to genome-wide association studies (GWAS), some single nucleotide polymorphisms (SNPs) are likely factors for prostate cancer.
Objective: The aim of this study was to investigate the association between the rs1859962 polymorphism and prostate cancer risk.
Material & Methods: This case-control study was conducted on 172 peripheral blood samples, including 72 cases of prostate cancer and 100 control subjects with BPH. The Tetra - ARMs PCR technique was used for SNP genotyping.
Results: The results showed that the GG genotype of the rs185996 polymorphism had a significant association with prostate cancer risk in the recessive model (P=0.022; OR=3.426; 95% CI=1.135-10.344). According to the results of the dominant and additive models, there is no risk of prostate cancer in these genetic models. The polymorphism Rs1859962 was correlated with GS≥8 (P=0.021; OR=2.088; 95%CI=1.11-3.928), EPE (P=0.002) and PSA>10 (P=0.016; OR=2.133; 95%CI=1.44-3.978).
Discussion & Conclusion: Our results suggest that the rs1859962 polymorphism is associated with prostate cancer risk in a recessive model and can be considered as a potential biomarker for screening prostate cancer patients.
Keywords: rs1859962, Single Nucleotide Polymorphism, Prostate Cancer
Full-Text [PDF 1550 kb]   (267 Downloads)    
Type of Study: Research | Subject: biology
Received: 2023/06/11 | Accepted: 2023/07/18 | Published: 2023/12/6
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Masori Z, Angaji S A, Karimi G, Beikzadeh B, Roudi R. Association of polymorphism rs1859962 with prostate cancer in Iranian men. J. Ilam Uni. Med. Sci. 2023; 31 (5) :85-93
URL: http://sjimu.medilam.ac.ir/article-1-8002-en.html
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Volume 31, Issue 5 (12-2023) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
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