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:: Volume 30, Issue 2 (6-2022) ::
Journal of Ilam University of Medical Sciences 2022, 30(2): 97-104 Back to browse issues page
Investigation of the Relationship between the rs8192688 Polymorphism of the FABP-4 Gene and Cardiovascular Disease Susceptibility in Type 2 Diabetic Patients in Ilam Province, Iran
Amin Bakhtiyari1 , Salar Bakhtiari * 2, Maryam Peymani1 , Karimeh Haghani1 , Siros Norozi3
1- Dept of Biology, Faculty of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran
2- Dept of Biology, Faculty of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran , bakhtiyaribio@gmail.com
3- Dept of Cardiology, Ilam University of Medical Sciences, Ilam, Iran
Abstract:   (1283 Views)
Introduction: Cardiovascular disease (CVD) is the most common cause of death in patients with type 2 diabetes (T2D). The association between diabetes and cardiovascular disease is complex and multifaceted. This study aimed to investigate the possible association between rs8192688 Polymorphism of the FABP-4 gene and the CVD susceptibility in T2DM patients in Ilam Province, Iran.
Material & Methods: The statistical population consisted of 210 cases (T2D patients with CVD [n=70], T2D patients without CVD [n=70], and healthy controls [n=70]). The frequency of polymorphisms was investigated using the Tetra-Primer-ARMS-PCR method.
(Ethic code: IR.IAU.SHK.1399.011)
Findings: The results showed that TG, HDL-C, and LDL-C in the T2D group with CVD were significantly increased, compared to those in the T2D group (P<0.05). The frequency rates of the CT genotype in the control, T2D, and T2D with CVD groups were 26%, 24%, and 295 (P=0.16), respectively. Moreover, the frequency rates of the TT genotype were 6%, 4%, and 4% (P=0.12), and the frequency rates of the T allele were 19%, 16%, and 19% (P=0.09), respectively. There was no significant relationship between this polymorphism and the studied groups.
Discussion & Conclusion: The results showed that TG, LDL-C, and HDL-C could have a role in the development of CVD in T2D patients; however, the rs8192688 polymorphism of the FABP4 gene was not involved in the development of CVD in T2D patients.
Keywords: Cardiovascular disease, FABP-4, Polymorphism, Type 2 diabetes
Full-Text [PDF 1119 kb]   (451 Downloads)    
Type of Study: Applicable | Subject: biochemistry
Received: 2021/07/17 | Accepted: 2021/07/18 | Published: 2022/06/5
References
1. 1. Rizza RA. Pathogenesis of fasting and postprandial hyperglycemia in type 2 diabetes.implications for therapy. Diabetes 2010. 59:2697-707. doi: 10.2337/db10-1032
2. 2. Riserus U, Willett WC, Hu FB. Dietary fats and prevention of type 2 diabetes. Prog Lipid Res 2009; 48:44-51. doi: 10.1016/j.plipres.2008.10.002
3. 3. van 't Riet E. Role of adiposity and lifestyle in the relationship between family history of diabetes and 20-year incidence of type 2 diabetes in U.S. women. Diabetes Care 2010; 33:763-7. doi: 10.2337/dc09-1586
4. 4. Yoon PW, Scheuner MT, Khoury MJ. Research priorities for evaluating family history in the prevention of common chronic diseases. Am J Prev Med 2003; 24: 128-35. DOI: 10.1016/s0749-3797(02)00585-8
5. 5. Melmed S. Williams textbook of endocrinology.ed. t. Edition. 2011; ISBN:9781437736007
6. 6. Nasiri M. Association of G-2548A polymorphism in the promoter of leptin gene with plasma leptin level and risk of type 2 diabetes. J Kerman Uni Med Sci 2013; 4: 70-77.
7. 7. Fuchsberger C. The genetic architecture of type 2 diabetes. Nature 2016; 536:41-47. doi: 10.1038/nature18642
8. 8. Gaulton KJ. Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nat Genet 2015; 47:1415-25. doi: 10.1038/ng.3437
9. 9. Wellen KE, Hotamisligil GS. Inflammation, stress and diabetes. J Clin Invest 2005; 115: 1111-9. doi: 10.1172/JCI25102
10. 10. Kannel WB. Lipids,diabetes and coronary heart disease. insights from the framingham study. Am Heart J 1985; 110:1100-7. doi: 10.1016/0002-8703(85)90224-8
11. 11. Taskinen MR. Diabetic dyslipidaemia. from basic research to clinical practice. Diabetologia 2003; 46:733-49. doi.org/10.1007/s00125-003-1111-y
12. 12. Solano MP, Goldberg RB. Management of dyslipidemia in diabetes. Cardiol Rev 2006; 14: 125-35. doi: 10.1097/01.crd.0000188034.76283.5e
13. 13. Ishimura S. Circulating levels of fatty acid-binding protein family and metabolic phenotype in the general population. PLoS One 2013; 8:e81318. doi.org/10.1371/journal.pone.0081318
14. 14. Furuhashi M. Fatty acid binding protein 4 (FABP4). pathophysiological insights and potent clinical biomarker of metabolic and cardiovascular diseases. Clin Med Insights Cardiol 2014; 8:23-33. doi: 10.4137/CMC.S17067
15. 15. Hotamisligil GS, Bernlohr DA. Metabolic functions of FABPs--mechanisms and therapeutic implications. Nat Rev Endocrinol 2015; 11:592-605. doi: 10.1038/nrendo.2015.122
16. 16. medicine Nlo. rs8192688. dbSNP. 2020.
17. 17. Medrano RFV, de Oliveira CA. Guidelines for the tetra-primer ARMS-PCR technique development. Mol biotech 2014; 56:599-608. doi: 10.1007/s12033-014-9734-4
18. 18. Orasanu G, Plutzky J. The pathologic continuum of diabetic vascular disease. J Am Coll Cardiol 2009; 53: S35-42. doi: 10.1016/j.jacc.2008.09.055
19. 19. Matheus AS. Impact of diabetes on cardiovascular disease. an update. Int J Hypertens 2013; 653789. doi: 10.1155/2013/653789
20. 20. Watts GF, Playford DA. Dyslipoproteinaemia and hyperoxidative stress in the pathogenesis of endothelial dysfunction in non-insulin dependent diabetes mellitus. an hypothesis. Atherosclerosis 1998; 141: 17-30. doi: 10.1016/s0021-9150 (98)00170-1
21. 21. Daousi C. Prevalence of obesity in type 2 diabetes in secondary care: association with cardiovascular risk factors. Postgrad Med J 2006; 82:280-4. doi: 10.1136/pmj.2005.039032
22. 22. Senemar S, Edraki MR, Toosi S. Association between type 2 diabetes mellitus, biochemical factors and UCSNP-43 polymorphisms of CALPIN-10 gene in patients with atherosclerosis of coronary artery disease in Southern Iran population. J Cardiovasc Thorac Res 2016; 8:13-9. doi: 10.15171/jcvtr.2016.03
23. 23. Zadhoush F, Sadeghi M, Pourfarzam M. Biochemical changes in blood of type 2 diabetes with and without metabolic syndrome and their association with metabolic syndrome components. J Res Med Sci 2015; 20:763-70. doi: 10.4103/1735-1995.168383
24. 24. Sattar N, Wannamethee SG, Forouhi NG. Novel biochemical risk factors for type 2 diabetes: pathogenic insights or prediction possibilities? Diabetologia 2008. 51: p. 926-940. doi: 10.1007/s00125-008-0954-7
25. 25. Adela R. Serum protein signature of coronary artery disease in type 2 diabetes mellitus. J Transl Med 2019; 17:17. doi.org/10.1186/s12967-018-1755-5
26. 26. Ye X. Serum triglycerides as a risk factor for cardiovascular diseases in type 2 diabetes mellitus: a systematic review and meta-analysis of prospective studies. Cardio Diabet 2019; 18:48. doi.org/10.1186/s12933-019-0851-z
27. 27. Kaftan A, Hussain M. Association of Adiponectin Gene Polymorphism rs266729 with Type Two Diabetes Mellitus in Iraqi Population. a pilot Study. Gene 2015; 570. doi: 10.1016/j.gene.2015.06.004
28. 28. Kannel WB. Lipids, diabetes, and coronary heart disease: Insights from the Framingham Study. American Heart J 1985;110:1100-107. doi: 10.1016/0002-8703(85)90224-8
29. 29. Wu Z. Different associations between HDL cholesterol and cardiovascular diseases in people with diabetes mellitus and people without diabetes mellitus. a prospective community-based study. American J Clinical Nutrition 2021; 114:907-13. doi: 10.1093/ajcn/nqab163
30. 30. Mansego ML. Common variants of the liver fatty acid binding protein gene influence the risk of type 2 diabetes and insulin resistance in Spanish population. PLoS One 2012; 7:e31853. doi.org/10.1371/journal.pone.0031853
31. 31. Ibarretxe D. FABP4 plasma concentrations are determined by acquired metabolic derangements rather than genetic determinants. Nutr Metab Cardiovasc Dis 2015; 25:875-80. doi: 10.1016/j.numecd.2015.05.008.
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Bakhtiyari A, Bakhtiari S, Peymani M, Haghani K, Norozi S. Investigation of the Relationship between the rs8192688 Polymorphism of the FABP-4 Gene and Cardiovascular Disease Susceptibility in Type 2 Diabetic Patients in Ilam Province, Iran. J. Ilam Uni. Med. Sci. 2022; 30 (2) :97-104
URL: http://sjimu.medilam.ac.ir/article-1-7189-en.html


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Volume 30, Issue 2 (6-2022) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
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