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Effect of Opium Addiction on T4, T3 and TSH in Male and Female Rats
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S Mami *   1, M Eghbali , A Khosravi , M Purmehdi Brojeni , A Salati , F Mami , R Hushmandfar |
| 1- , s.mami@ilam.ac.ir |
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Abstract: (55689 Views) |
| Introduction: Opium addiction is a serious social problem in Iran. Beside the social effects, opium addiction has various physiologic consequences. Thyroid horm-ones have a direct effect on metabolism and at present study the effects of opium addiction on thyroid stimulating hormone (TSH), triiodothyronine (T3) and thyroxin (T4) was evaluated.
Materials & Methods: 60 rats (30 male and 30 female weighting 250-300g) were rando-mly divided into control and addicted groups. Addicted groups received opium solution in gavage for 60 days, by the end of the study, blood samples were taken from all groups and T4, T3 and TSH of addicted group were compared with control groups.
Findings: In male and female addicted rats T4 decreased and TSH increased but T3 did not alter significantly.
Discussion & Conclusion: It can be concluded that addication to opium can cause an increase in TSH hormone and a decrease in T4 but no effect on T3. It can also be claimed that opium addiction can affect on the thyroid gland function |
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| Keywords: addiction, opium, thyroid hormone, rat |
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Full-Text [PDF 161 kb]
(4995 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2012/08/11 | Accepted: 2013/04/17 | Published: 2013/04/17
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