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:: Volume 28, Issue 6 (1-2021) ::
Journal of Ilam University of Medical Sciences 2021, 28(6): 62-69 Back to browse issues page
Evaluation of 45bp Ins/Del Genetic Variant in UCP-2 Gene as a Risk factor for Bipolar Disorder
Leila Kohan * 1, Fateme Zarei2 , Ebrahim Moghimi Sarani3
1- .Dept of Biology, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran , leila_kohan@yahoo.com
2- Yong Researchers and Elite Club, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran
3- Research Center for Psychiatry and Behavioral Sciences, Department of Psychiatry, Shiraz University of Medical Sciences, Shiraz, Iran
Abstract:   (1923 Views)
Introduction: Bipolar disorder is a type biphasic disorder of energy availability that indicates increased mitochondrial respiration in episodes of mania, compared to decreased mitochondrial function in the depressive phase of the illness. Mitochondrial dysfunction may lead to an excessive increase in reactive oxygen species (ROS). The UCP-2 proteins act as regulators of ROS in the cell. This study aimed to investigate the association of UCP-2 45bp ins/del genetic variant with susceptibility to bipolar disorder.
 
Materials & Methods: This case-control study was performed on 205 subjects with bipolar disorder and 200 healthy subjects as a control group. After extraction of DNA from peripheral blood samples, genotype determination was performed using the PCR method. Moreover, the logistic regression analysis was used for the comparison of genotypes and allele frequencies between case and control groups.
Ethics code: IR.SUMS.REC.1396.S435
 
Findings: There was a significant association between ID (OR=0.42; 95% CI= 0.27-0.64; P<0.001) and II (OR=0.39; 95% CI=0.20-0.77; P=0.006) genotypes with bipolar disorder. Data analysis showed I allele had a protective effect on susceptibility to bipolar disorder (OR=0.56; 95% CI=0.42-0.75; P<0.001).
 
Discussions & Conclusions: This study investigated, for the first time, the association between UCP-2 45bp ins/del genetic variant and bipolar disorder. The results showed UCP-2 45bp ins/del genetic variant was associated with bipolar disorder; however, more studies are required to be conducted in different ethnicities to confirm these results.
Keywords: Bipolar disorder, Genetic variant, Mitochondria, UCP-2
Full-Text [PDF 838 kb]   (499 Downloads)    
Type of Study: Research | Subject: biology
Received: 2020/03/30 | Accepted: 2020/10/31 | Published: 2021/02/28
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Kohan L, Zarei F, Moghimi Sarani E. Evaluation of 45bp Ins/Del Genetic Variant in UCP-2 Gene as a Risk factor for Bipolar Disorder. J. Ilam Uni. Med. Sci. 2021; 28 (6) :62-69
URL: http://sjimu.medilam.ac.ir/article-1-6433-en.html
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Volume 28, Issue 6 (1-2021) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
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