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:: Volume 28, Issue 2 (6-2020) ::
Journal of Ilam University of Medical Sciences 2020, 28(2): 11-20 Back to browse issues page
Association between Catalase Gene (CAT-262 C/T) Polymorphism and Preeclampsia in the South of Iran
Marzieh Alipour1 , Sirous Naeimi * 2, Mohammad Mahdi Moghanibashi1 , Khalil Khasheivarnamkhasti1 , Zeynab Mahmmodian1
1- Dept of Genetics, Faculty of Basic Sciences, Kazerun Branch, Islamic Azad University, Kazerun, Iran
2- Dept of Genetics, Faculty of Basic Sciences, Kazerun Branch, Islamic Azad University, Kazerun, Iran , Naeimis@kau.ac.ir
Abstract:   (1846 Views)
Introduction: The cause of preeclampsia has not been identified so far; therefore, it accounts for a high percentages of maternal hospitalization. It seems that polymorphisms of genes encoding antioxidant system enzymes are effective in the pathophysiology of this disorder. This study aimed to evaluate the relationship between CAT-262 C/T polymorphism of enzymatic antioxidant Catalase gene and preeclampsia.
 
Materials & Methods: This case-control study was conducted at Islamic Azad University of Kazerun, Kazerun, Iran, in 2017. In total, 150 preeclampsia patients and 150 healthy pregnant women were selected as cases and controls, respectviely.  After DNA sampling and extraction, the CAT-262 C/T polymorphism was determined by Polymerase Chain Reaction and Restriction Fragment Length Polymorphism method. Data were analyzed in SPSS software using the Chi-square and Yates corrected X 2 statistical tests. Ethics code: IR.IAU.KAU.REC.1398.005
 
Findings: Results showed a significant difference between preeclampsia patinets and healthy preganat women regarding the frequency of CC, CT, and TT genotypes (PCAT=0.32) and both C and T alleles (PCAT=0.42) in the position of the CAT-262 C/T polymorphism of enzymatic antioxidant Catalase gene. Except for the multiple pregnancy parameter (PCAT=0.007), no significant diffrences were observed between the case and control groups in terms of other measured factors, such as the severity of preeclampsia (PCAT=0.272), urinary protein excretion (PCAT=0.130), patient swelling (PCAT=0.739), age at onset of disease (PCAT=0.412), primipara (PCAT=0.322), multipara (PCAT=0.074), previous history of preeclampsia (PCAT=0.630), history of miscarriage (PCAT=0.287), diabetes mellitus (PCAT=0.75), and hypothyroidism (PCAT=0.941).
 
Discussion & Conclusions: According to the results of this study, the CAT-262C/T polymorphism could be considered as a risk factor for preeclampsia susceptibility in the south of Iran.
 
Keywords: Catalase, CAT-262 C/T polymorphism, Preeclampsia
Full-Text [PDF 983 kb]   (478 Downloads)    
Type of Study: Research | Subject: genetic mlvkly
Received: 2020/01/3 | Accepted: 2020/02/24 | Published: 2020/06/30
References
1. Muchemi OM, Gichogo AW. Maternal mortality in central province, Kenya, 2009-2010. Pan Af Med J2014; 17: 201. doi. 10.11604/pamj.2014.17.201.3694
2. Sharemi SH, Milani F, Zahiri Z, Zendedel M, Salamat F, Rafipour B, et al. [Comparison of Pre-eclampsia risk factors regarding to its severity in pregnant women referred to Alzahra hospital of Rasht. Iranian J Obste Gynecol Infert 2013; 16: 1-8. (Persion)
3. Gibbs RS, Karlan BY, Haney AF, Nygaard I. Danforths obstetrics and gynecology. 10th ed Philadelphia Lippincott Wiliams Wilkins Publication; 2008.
4. Hinton L, Tucker KL, Greenfield SM, Hodgkinson JA, Mackillop L, Mccourt C, et al. Blood pressure self-monitoring in pregnancy feasibility study a qualitative analysis of womens experiences of self-monitoring. Bio Med Cent Preg Child 2017; 17: 427. doi. 10.1186/s12884-017-1592-1
5. Williams B, Poulter NR, Brown MJ, Davis M, McInnes GT, Potter JF, et al. Guidelines for management of hypertension: Report of the fourth working party of the British hypertension society 2004-BHS IV. Journal of Human Hypertension 2004; 18: 139-85. doi. 10.1038/sj.jhh.1001683
6. Williams PJ, Morgan L. The role of genetics in Pre eclampsia and potential pharmacogenomic interventions. Pharmacogenom Personal Med2012; 5: 37–51. doi.10.2147/PGPM.S23141
7. Duckitt K, Harrington D. Risk factors for pre eclampsia at antenatal booking systematic review of controlled studies. BMJ 2005; 330: 656. doi.10.1136/bmj.38380.674340.E0
8. Serdar Z, Gur E, Colakogullari M, Develioglu O, Sarandol E. Lipid and protein oxidation and antioxidant function in women with mildand severe preeclampsia. Arch Gynecol Obstet 2003; 268:19-25. doi. 10.1007/s00404-002-0302-y
9. Myatt L. Placental adaptive responses and fetal programming. J Physiol2006; 572:25-30.‌ doi.10.1113/jphysiol.2006.104968
10. Halliwell B. Oxidative stress and cancer have we moved forward? Biochem J 2007 1;401:1-1. doi. 10.1042/BJ20061131
11. Halliwell B. Free radicals reactive oxygen species and human disease a critical evaluation with special reference to atherosclerosis. Br J Exp Pathol 1989; 70: 737-57.
12. Costa A, Scholerdahirel A, Mechtagrigoriou F. The role of reactive oxygen species and metabolism on cancer cells and their microenvironment. Sem Cancer Biol 2014; 25: 23-32. doi.10.1016/j.semcancer.2013.12.007
13. Ahn J, Nowell S, McCann SE, et al. Associations between catalase phenotype and genotype: modification by epidemiologic factors. Cancer Epidemiol Biomarkers Prev 2006; 15: 1217-22. doi.10.1158/1055-9965.EPI-06-0104
14. Ding G, Liu F, Shen B, Feng C, Xu J, Ding Q. The association between polymorphisms in prooxidant or antioxidant enzymes myeloperoxidase SOD2 and CAT and genes and prostate cancer risk in the Chinese population of Han nationality. Clin Gen cancer 2012; 10 : 251-5. doi..org/10.1016/j.clgc.2012.08.001
15. Yassaee F, Salimi S, Etemadi S, Yaghmaei M. Comparison of CAT-21A/T Gene Polymorphism in Women with Preeclampsia and Control Group. Adv Biomed Res 2018; 7.‌133. doi.10.4103/abr.abr_36_18
16. Upadhyaya C, Mishra S, Singh P, Sharma P. Antioxidant status and peroxidative stress in mother and newborn. Indian J Clin Biochem 2005; 20: 30-34. doi. 10.1007/BF02893038
17. Little R E, Gladen B C. Levels of lipid peroxides in uncomplicated pregnancy a review of the literature. Rep Toxicol 1999; 13: 34752. doi.10.1016/s0890-6238(99)00033-7
18. Jauniaux E, Watson AL, Hempstock J, Bao YP, Skepper JN, Burton GJ. Onset of maternal arterial blood flow and placental oxidative stress a possible factor in human early pregnancy failure. Am J Pathol 2000; 157: 2111-22. doi. 10.1016/S0002-9440(10)64849-3
19. Mutinati M, Piccinno M, Roncetti M, Campanile D, Rizzo A, Sciorsci RL. Oxidative stress during pregnancy In the sheep. Rep Dom Anim2013; 48: 353–357. DOI: 10.1111/rda.12141
20. Lushchak VI. Environmentally induced oxidative stress in aquatic animals. Aquat Toxicol 2011; 101:13-30. doi. 10.1016/j.aquatox.2010.10.006
21. Hung TH , Lo LM, Chiu TH, Li MJ, Yeh YL, Chen SF, etal . A Longitudinal Study of Oxidative Stress and Antioxidant Status in Women With Uncomplicated Pregnancies Throughout Gestation. Reprod Sci 2010; 17: 401-409. doi. 10.1177/1933719109359704
22. Llurba E, Gratacos E, Martingallan P, Cabero L, Dominguez C. A comprehensive study of oxidative stress and antioxidant status in preeclampsia and normal pregnancy. Free Rad Biol Med 2004; 37: 557-70. doi. 10.1016/j.freeradbiomed.2004.04.035
23. Gupta S, Agarwal A, Sharma RK. The role of placental oxidative stress and lipid peroxidation in preeclampsia. Obstet Gynecol Surv 2005; 12: 807- 16. doi. 10.1097/01.ogx.0000193879.79268.59
24. Burton GJ, Yung HW, Cindrovadavies T, Charnockjones DS. Placental endoplasmic reticulum stress and oxidative stress in the pathophysiology of unexplained intrauterine growth restriction and early onset preeclampsia. Placenta 2009; 30: 43-8. doi. 10.1016/j.placenta.2008.11.003
25. Shaker OG, Sadik NA. Pathogenesis of preeclampsia Implications of apoptotic markers and oxidative stress. Hum Exp Toxicol 2013; 32: 11708. doi.10.1177/0960327112472998
26. Can M, Guven B, Bektas S, Arikan I. Oxidative stress and apoptosis in preeclampsia. Tissue Cell 2014; 46: 477-81. doi. 10.1016/j.tice.2014.08.004
27. Vanderlelie J, Venardos K, Clifton V.L, Gude N.M, Clarke F.M, Perkins A.V. Increased biological oxidation and reduced anti oxidant enzyme activity in pre eclamptic placentae. Placenta 2005; 26: 53-8. doi. 10.1016/j.placenta.2004.04.002
28. Ichimura Y, Habuchi T, Tsuchiya N, Wang L, Oyama C, Sato. Increased risk of bladder cancer associated with a glutathione peroxidase 1 codon 198 variant. J Urol2004; 172: 728-32.‌ doi. 10.1097/01.ju.0000130942.40597.9d
29. Ravnharen G, Olsen A, Tjonneland A, Dragsted LO, Nexo BA, Wallin H. Associations between GPX1 Pro198Leu polymorphism erythrocyte GPX activity alcohol consumption and breast cancer risk in a prospective cohort study. Carcinogenesis 2005; 27 : 8205.‌ doi. 10.1093/carcin/bgi267
30. Kodydkova J, Vávrova L, Kocik M, Zak A. Human catalase its polymorphisms regulation and changes of its activity in different diseases. Folia Biol 2014; 60: 153-67.‌
31. Kuzuya M, Ando F, Iguchi A, Shimokata H. Glutathione peroxidase 1 Pro198Leu variant contributes to the metabolic syndrome in men in a large Japanese cohort. Am J Clin Nutr 2008;87: 1939-44. doi.10.1093/ajcn/87.6.1939
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Alipour M, Naeimi S, Moghanibashi M M, Khasheivarnamkhasti K, Mahmmodian Z. Association between Catalase Gene (CAT-262 C/T) Polymorphism and Preeclampsia in the South of Iran. Journal of Ilam University of Medical Sciences 2020; 28 (2) :11-20
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Volume 28, Issue 2 (6-2020) Back to browse issues page
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