[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 28, Issue 3 (8-2020) ::
Journal of Ilam University of Medical Sciences 2020, 28(3): 63-69 Back to browse issues page
Renal Transplantation and Hyperuricemia
Sima Golmohammadi * 1, Hamidreza Omrani2, Zahra Ghorbani3, Mahin Moradi4
1- Dept of Internal Medicine, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran , simag_2000@yahoo.com
2- Dept of Internal Medicine, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
3- Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
4- Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
Abstract:   (1566 Views)
Introduction: The adverse effects of hyperuricemia on renal function are of interest. Patients with a history of kidney transplantation are at the risk of hyperuricemia and its associated complications. Therefore, the identification and management of the factors that cause hyperuricemia in these patients can be helpful and may eliminate the need for taking uric acid-lowering drugs. This study aimed to determine the prevalence of hyperuricemia and its related factors in patients who underwent renal transplantation.
 
Materials & Methods: This analytical cross-sectional study was conducted on patients over 18 years of age who underwent kidney transplantation and referred to Mahdieh Clinic in Kermanshah, Iran, during 2019.  The sampling was performed using the available and purposeful method. Ethics code: KUMS.REC.1396.574  
 
Findings: This study was performed on 165 patients with renal transplantation. The prevalence of hyperuricemia in this study was obtained at 58.8%. The hyperuricemic patients had a lower glomerular filtration rate and higher proteinuria (P<0.05). High levels of uric acid were significantly associated with male gender, and the consumption of diuretic medications as well as immunosuppressive drugs, especially cyclosporine (P<0.05).
 
Discussion & Conclusions: In this study, hyperuricemia was highly prevalent in patients with kidney transplantation and was associated with poorer kidney function. It seems that early diagnosis of hyperuricemia and the implementation of some actions, such as less diuretic usage and selection of immunosuppressive drugs with less hyperuricemic effects, can improve the function and survival of the transplanted kidney with fewer needs for the use of uric acid-lowering drugs.
 
Keywords: Diuretic, Hyperuricemia, Immunosuppressive drugs, Renal transplantation, Uric acid lowering drugs
Full-Text [PDF 680 kb]   (627 Downloads)    
Type of Study: Applicable | Subject: Internal operations( nursing )
Received: 2019/10/17 | Accepted: 2020/01/15 | Published: 2020/08/31
References
1. Hernandez D, Trinanes J, Maria Armas A, Ruizesteban P, Alonsotitos J, Duarte A, et al. Vascular damage and kidney transplant outcomes: an unfriendly and harmful link. Am J Med Sci 2017; 354:7-16. doi.10.1016/j.amjms.2017.01.004.
2. Baroletti S, Bencivenga GA, Gabardi S. Treating gout in kidney transplant recipients. Prog Transplant2004; 14:143–147. doi.10.7182/prtr.14.2. dr3j76l1603k0145
3. Kim KM, Kim SS, Han DJ, Yang WS, Park JS, Park SK. Hyperuricemia in kidney transplant recipients with intact graft function. Transplant Proc2010; 42: 3562-7. doi.10.1016/j.transproceed.2010.07.104.
4. Mazzali M. Uric acid and transplantation. Semin Nephrol2005; 25: 50-5. doi.10.1016/j.semnephrol.2004.09.008.
5. Lin HY, Rocher LL, Mcquillan MA, Schmaltz S, Palella TD, Fox IH. Cyclosporin induced hyperuricemia and gout. N Engl J Med1989; 321:287-92. doi.10.1056/NEJM198908033210504.
6. West C, Carpenter BJ, Halaka TR. The incidence of gout in renal transplantation. Am J Kid Dis1987; 10:369-72. doi.10.1016/s0272-6386(87)80103-8.
7. Wang JG, Staessen JA, Fagard RH, Birkenhager WH, Gong L, Liu L. Prognostic significance of serum creatinine and uric acid in older Chinese patients with isolated systolic hypertension. Hypertension 2001; 37:1069-74. doi.10.1161/01.hyp.37.4.1069.
8. Gerhardt U, Grobe Huttman M, Hohage H. Influence of hyperglycemia and hyperuricemia on long‐term transplant survival in kidney transplant patients. Clin Transplant 1999; 13:375-9. doi.10.1034/j.1399-0012.1999.130502. x.
9. Bandukwala F, Huang M, Zaltzman JS, Nash MM, Prasad GV. Association of uric acid with inflammation, progressive renal allograft dysfunction and post-transplant cardiovascular risk. Am J Cardiol 2009; 103:867-871. doi.10.1016/j.amjcard.2008.11.042.
10. Mazzali M, Kim YG, Suga S, Gordon KL, Kang DH, Jefferson JA et al. Hyperuricemia exacerbates chronic cyclosporin nephropathy. Transplantation 2001; 71:900-5. doi.10.1097/00007890-200104150-00014.
11. Filiopoulos V, Hadjiyannakos D, Vlassopoulos D. New insights into uric acid effects on the progression and prognosis of chronic kidney disease. Ren Fail 2012; 34:510-20. doi.10.3109/0886022X.2011. 653753.
12. Kanellis J, Watanabe S, Li JH, Kang DH, Li P, Nakagawa T, et al. Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase2. Hypertension 2003; 41:1287-93. doi.10.1161/01.HYP.0000072820.07472.3B.
13. deFilippi C, Wasserman S, Rosanio S, Tiblier E, Sperger H, Tocchi M, et al. Cardiac troponin T and C-reactive protein for predicting prognosis, coronary atherosclerosis, and cardiomyopathy in patients undergoing long term hemodialysis. JAMA 2003; 290:353-9. doi.10.1001/jama.290.3.353.
14. kang D, Park S, Lee I, Johnson R. Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells. J Am Soc Nephrol2005; 16:3553-62. doi: 10.1681/ASN.2005050572.
15. Golmohammadi S, Almasi A, Manouchehri M, Omrani HR, Zandkarimi MR. An Allopurinol against progression of chronic kidney disease. Iran J Kid Dis 2017; 11:286-293.
16. Einollahi B, Einollahi H, Nafar M, Rostami Z. Prevalence and risk factors of hyperuricemia among kidney transplant recipients. Indian J Nephrol 2013; 23: 201-5. doi.10.4103/0971-4065.111849.
17. Bandukwala F, Huang M, Prasad GV. Role of uric acid in post renal transplantation human vascular cells. Transplant Proc 2009; 41: 1634-6. doi.10.1016/j.transproceed. 2009.01.098.
18. Kanbay M, Akcay A, Huddam B, Usluogullari CA, Arat Z, Ozdemir FN et al. Influence of cyclosporine and tacrolimus on serum uric acid levels in stable kidney transplant recipients. Transplant Proc 2005; 37: 3119-20. doi.10.1016/j.transproceed.2005.08.042.
19. Zhang K, Gao B, Wang Y, Wang G, Wang W, Zhu Y et al. Serum uric acid and renal transplantation outcomes: at least 3-year post-transplant retrospective multivariate analysis. PLos One 2015; 10: 0133834. doi.10.1371/journal.pone.0133834.
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Golmohammadi S, Omrani H, Ghorbani Z, Moradi M. Renal Transplantation and Hyperuricemia. Journal of Ilam University of Medical Sciences 2020; 28 (3) :63-69
URL: http://sjimu.medilam.ac.ir/article-1-6080-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 28, Issue 3 (8-2020) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
Persian site map - English site map - Created in 0.14 seconds with 31 queries by YEKTAWEB 4541