1- Metabolic Disease Research Center, Qazvin University of Medical Science, Qazvin, Iran 2- Ilam University of Medical Sciences 3- Metabolic Disease Research Center, Qazvin University of Medical Science, Qazvin, Iran , ramak.ghavam@yahoo.com
Abstract: (29259 Views)
Background: Heart disease, particularly coronary heart disease is a major cause of mortality among patients with diabetes mellitus. High level of hs-CRP is considered as a risk factor for heart diseases. Treatment with pioglitazone in patients with or without type II diabetes decreases serum concentrations of hs-CRP. The purpose of this study was to compare the effects of pioglitazone and metformin on hs-CRP level.
Material and methods: A randomized clinical trial was performed on 40 patients with type 2 diabetes and defined inclusion criteria. Patients were divided into two groups receiving metformin and pioglitazone. Blood levels of cholesterol, triglycerides, fasting blood glucose, Alanine transaminase, Aspartat aminotransferase, HbA1C and hs-CRP were measured in all subjects before and after 3 month drug therapy. The average change in each group before and after drug therapy were analyzed by paired T-test, the mean change between groups were compared by T-test.
Results: In both groups, hs-CRP level was significantly decreased after drug therapy. The mean change of hs-CRP, HbA1C, cholesterol was significantly higher in metformin treated group.
Conclusion: Since the average reduction in the level of hs-CRP, cholesterol and HbA1C in diabetic patients treated with metformin is significantly higher than patients treated with pioglitazone treatment with metformin is recommended to reduce risk of heart disease
Ziaee A, Hashemipour S, Ghavam S, Javadi A, Ghavam R, Barikani A et al . Comparison of metformin and pioglitazone on hs-CRP levels in patients with Type II diabetes. J. Ilam Uni. Med. Sci. 2013; 21 (2) :28-36 URL: http://sjimu.medilam.ac.ir/article-1-596-en.html