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:: Volume 28, Issue 1 (3-2020) ::
Journal of Ilam University of Medical Sciences 2020, 28(1): 47-55 Back to browse issues page
Association between Polymorphism rs3746444 (A/G) Mir-499 and Ovarian Cancer in Iranian Female Population
Nahid Masoudi Ashtiani1 , Kasra Esfahani * 2, Fatemeh Shahbazi1
1- Dept of Biology, Payame Noor University, Ray Branch, Tehran, Iran
2- National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran , kasra13@nigeb.ac.ir
Abstract:   (2429 Views)
Introduction: Ovarian cancer is one of the most prevalent cancers among women. According to several reports micro RNA-499 is involved in the development of ovarian carcinoma. The presence of Single Nucleotide Polymorphisms (SNPs) in miRNA sequences can also affect the risk of cancer. The aim of this study was to investigate the association between SNP mir-499 rs3746444 and the ovarian cancer in the Iranian female population.
 
Materials & Methods: In this case-control study, peripheral blood samples were taken from 35 patients with ovarian cancer referred to Imam Khomeini Hospital and Cancer Institute and 35 healthy individuals. Subsequently, the DNA was extracted, and the polymorphism was investigated using Arms- polymerase chain reaction method. The data was analyzed in SPSS software. Ethics code: IR.PNU.REC.1398.118
Findings: The results of investigating SNP rs3746444 mir-499 between the two groups of patients and control indicated that the genotype frequencies of AA, AG, and GG were % 2.9, % 51.4, and % 45.7 in the patients and %14.3, % 45.7, and % 40 in the controls, respectively.
 
Discussion & Conclusions: According to the results of the study, there was no significant difference between the healthy and patient samples regarding the frequencies of genotypes ([χ2 (1, 70) =0.23, P=0.63]); however, according to odds ratio, the risk of developing ovarian cancer is higher in the GG genotype (Odds Ratio=1.26, 95% CI: 0.49-3.26).
 
Keywords: Ovarian cancer, Mir-499, Rs3746444
Full-Text [PDF 662 kb]   (1133 Downloads)    
Type of Study: Research | Subject: genetic mlvkly
Received: 2019/05/18 | Accepted: 2019/10/21 | Published: 2020/03/29
References
1. Stewart BW, Wild CP. World Cancer Report.2014; P.12.
2. Cannistra, SA. Cancer of the ovary. N Engl J Med 2004; 351: 2519-29. doi.10.1056/NEJMra041842
3. Tinger A, Waldron T, Peluso N, Katin MJ, Dosoretz DE, Blitzer PH, et al. Effective palliative radiation therapy in advanced and recurrent ovarian carcinoma. Int J Radiat 2001; 51:1256-63. doi. 10.1016/S0360-3016(01)01733-3
4. Guppy AE, Nathan PD, Rustin GJS. Epithelial ovarian cancer. Clin Oncol 2005; 17:399-411. doi.10.1016/j.clon.2005.05.009
5. Devita VT, Heliman S, Rosenberg SA. Cancer. Prin Pract Oncol 2001; 1: 4450-4
6. Colombo N. Ovarian cancer. Crit Rev Oncol Hematol 2006.60:59-79. doi. 10.1016/j.critrevonc.2006.03.004
7. Reynolds EA, Moller KA. A review and an update on the screening of epithelial ovarian cancer. Curr Probl Cancer 2006; 30:203. doi:10.1016/j.currproblcancer.2006.06.001
8. Gomezraposo C, Mendiola M, Barriuso J, Hardisson D, Redondo A. Molecular characterization of ovarian cancer by gene expression profiling. Gynecol Oncol 2010; 118:88-92. doi. 10.1016/j.ygyno.2010.03.012
9. Grover SR, Quinn MA. Is there any value in bimanual pelvic examination as a screening test? Med J Aust 1995; 162:408-10. doi:10.5694/j.1326-5377.1995.tb139967.x
10. Speicher M, Antonarakis SE, Motulsky AG. Human genetics problems and approaches. 1th ed. Springer Sci Bus Med Publication.2009 ;P.230-52.
11. Sun G, Yan J, Noltner K, Feng J, Li H, Sarkis DA, et al. SNPs in human miRNA genes affect biogenesis and function. Rna 2009; 15:1640-51. doi.10.1261/rna.1560209
12. Ma XP, Zhang T, Peng B, Yu L, Jiang DK. Association between microRNA polymorphisms and cancer risk based on the findings of 66 case control studies. Plos One 2013; 8:79584. doi.10.1371/journal.pone.0079584
13. Takahashi RU, Miyazaki H, Ochiya T. The roles of microRNAs in breast cancer. Cancers 2015; 7:598-616. doi.10.3390/cancers7020598
14. Esquelakerscher A, Slack FJ. Oncomirs microRNAs with a role in cancer. Nat Rev Cancer 2006; 6:259-69. doi. 10.1038/nrc1840
15. Olive V, Bennett MJ, Walker JC, Ma C, Jiang I, Cordon C, et al. MicroR-19 is a key oncogenic component of mir17-92. Genes Dev 2009; 23:2839-49. doi.10.1101/gad.1861409
16. Shan Y, Shen N, Han L, Chen Q, Zhang J, Long X, et al. MicroRNA-499 Rs3746444 polymorphism and biliary atresia. Dig Liver Dis 2016; 48:423-8. doi.10.1016/j.dld.2015.11.014
17. Chen W, Shao D, Gu H, Gong J, Zhang J. Has mir 499 rs3746444 T/C polymorphism is associated with increased risk of coronary artery disease in a Chinese population. Acta Cardiol Sin 2017; 33:34. doi. 10.6515/ACS20160303A
18. Mu K, Wu ZZ, Yu JP, Guo W, Wu N, Wei LJ, et al. Meta-analysis of the association between three microRNA polymorphisms and breast cancer susceptibility. Oncotarget 2017; 8:68809. doi. 10.18632/oncotarget.18516
19. Hu M, Zhao L, Hu S, Yang J. The association between two common polymorphisms in MicroRNAs and hepatocellular carcinoma risk in Asian population. PLos One 2013; 8:57012. doi.10.1371/journal.pone.0057012
20. Ni J, Huang Y. Role of polymorphisms in miR146a and miR149 and miR196a2 and miR499 in the development of ovarian cancer in a Chinese population. Int J Clin Exp Pathol 2016; 9:5706-11.
21. Wang JX, Jiao JQ, Li Q, Long B, Wang K, Liu JP, et al. miR499 regulates mitochondrial dynamics by targeting calcineurin and dynamin related protein1. Nat Med 2011; 17:71. doi.10.1038/nm.2282
22. Naderi M, Hashemi M, Khorgami P, Koshki M, Ebrahimi M, Amininia S, et al. Lack of association between miRNA146a rs2910164 and miRNA499 rs3746444 gene polymorphisms and susceptibility to pulmonary Tuberculosis. IJMCM 2015; 4:40.
23. Liu Y, Xiong L, Zhou Y, Zheng B, Liu T, Xie W. Association of three polymorphisms rs11614913 rs2910146 and rs3746444 in miRNA196a2 miRNA146a and miRNA499 with inflammatory bowel disease a systematic review and meta-analysis. Gast Res Pract 2018;2:144-51.doi.org/10.1155/2018/7295131
24. Thakur N, Singhal P, Mehrotra R, Bharadwaj M. Impacts of single nucleotide polymorphisms in three microRNAs on the susceptibility to cervical cancer among Indian women. Biosci Rep 2019; 39:71-6. doi. 10.1042/BSR20180723
25. Zou D, Liu C, Zhang Q, Li X, Qin G, Huang Q, Meng Y, Chen L, Wei J. Association between polymorphisms in microRNAs and ischemic stroke in an Asian population evidence based on 6,083 cases and 7,248 controls. Clin Int Ag2018; 13:1709.
26. doi.org/10.2147/CIA.S174000
27. Lukacs J, Soltesz B, Penyige A, Nagy B, Poka R. Identification of miR146a and miR196a 2 single nucleotide polymorphisms at patients with high grade serous ovarian cancer. J Biotechnol 2019; 297:54-7. doi.10.1016/j.jbiotec.2019.03.016
28. Liu X, Xu B, Li S, Zhang B, Mao P, Qian B, et al. Association of SNPs in miR146a miR196a2 and miR499 with the risk of endometrial ovarian cancer. Acta Biochim Biophys Sin 2015; 47:564-6. doi. 10.1093/abbs/gmv042
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Masoudi Ashtiani N, Esfahani K, Shahbazi F. Association between Polymorphism rs3746444 (A/G) Mir-499 and Ovarian Cancer in Iranian Female Population. J. Ilam Uni. Med. Sci. 2020; 28 (1) :47-55
URL: http://sjimu.medilam.ac.ir/article-1-5685-en.html


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Volume 28, Issue 1 (3-2020) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
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