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Comparative Study of Intraperitoneal Injection
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H Hatami *   1, S Mohseni , F Shaikhzadeh , F Nejati |
| 1- , homeirahatami@yahoo.com |
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Abstract: (14792 Views) |
| Introduction: Alteration of abusing pattern of addictive drugs from classic opioid to ps-ychostimulant drugs threatens young people life. Glass abusing has been increasing am-ong young adult, although this drug has not been incoming Iran for a long time. The main compound of glass is methamphet-amine. Heroin and glass in addition to nervous system have very toxic effects on cardiovascular system. The aim of this study was to compare the toxic effects of heroin and glass exposure on the blood and serum parameters.
Materials & Methods: Male adult rats were given intraperitoneal injection of heroin or glass (10 mg/kg, once per day) for 15 days. At the end of 15 days, the blood samples were taken from rats and analyzed for red blood cells, white blood cells, platelets, cholesterol, triglyceride, LDL and HDL.
Findings: Our data showed that glass sign-ificantly decreased the total red blood cells, white blood cells, hemoglobin and haem-atocrit(P<0.05). Also, heroin decreeased the level of hemoglobin(P<0.05). Serum trigly-ceride, cholesterol and HDL did not change significantly in heroin and glass group wh-en compared to control group. The level of LDL in heroin group significantly decree-sed compared to glass group. (P<0.05)
Discussion & Conclusion: Industrial psyc-hostimulant drugs in comparison with clas-sic opioids have more impairing effects on blood factors and during short time lead to cardiovascular problems, anemia, weak-ening immune system and, ultimately pre-dispose addicted people to infectious disea-ses. |
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| Keywords: heroin, glass, serum and blood parameters |
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Full-Text [PDF 382 kb]
(6544 Downloads)
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Type of Study: Research |
Subject:
biology
Received: 2011/12/28 | Accepted: 2013/08/6 | Published: 2013/09/1
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