[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
Publication Ethics::
Peer Review Process::
Indexing Databases::
For Authors::
For Reviewers::
Subscription::
Contact us::
Site Facilities::
::
Google Scholar Metrics

Citation Indices from GS

AllSince 2019
Citations63083617
h-index2719
i10-index18578

..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Registered in

AWT IMAGE

AWT IMAGE

..
:: Volume 27, Issue 1 (4-2019) ::
Journal of Ilam University of Medical Sciences 2019, 27(1): 104-111 Back to browse issues page
Effect of Seizure on the Rate of Depression in Pregnant Mice Treated with Pentylenetetrazol
Ayoob Sabaghi1 , Ali Heyrani * 2, Amir Kiani3 , Namdar Yousofvand4
1- Dept of Motor Behavior, Faculty of Physical Education and Sport Sciences, Razi University, Kermanshah, Iran
2- Dept of Motor Behavior, Faculty of Physical Education and Sport Sciences, Razi University, Kermanshah, Iran , iliaheirani2004@gmail.com
3- Faculty of Pharmacology, Kermanshah University of Medical Sciences, Kermanshah, Iran
4- Faculty of Biology, Razi University, Kermanshah, Iran
Abstract:   (3326 Views)
Introduction: Depression is one of the most important psychological disorders in people with epilepsy. However, the effect of seizure on depression during pregnancy has not been studied experimentally. Therefore, the purpose of this study was to examine the effect of Seizure on depression in pregnant mice under treatment with pentylenetetrazol (PTZ).
 
Materials & Methods: After pregnancy stabilization in mice, one group was classified as the naive group.  the rest of the kindled mice were assigned into three groups including: seizure induction group between the 14th and 19th days of pregnancy once in 48 hours, the sham group received normal saline equal to PTZ intraperitoneally on the 14th and 19th days of pregnancy once in 48 hours and the control group which consisted of pregnant mice kindled without injection during pregnancy. The rate of depression in pregnant mice was measured between 14th and 19th days of pregnancy once in 48 hours and two h after PTZ injection using Forced Swim Test.
 
Findings: The results showed that depression in PTZ-treated pregnant mice was significantly higher than in other groups; moreover, the difference was statistically significant (P<0.05).
 
Discussion & Conclusions: According to the obtained results, seizure in pregnancy results in the increase of drpression levels consequently, it is necessary to identify patients in order to prevent them from depression and therefore avoid negative effects of depression on offspring.
 
Keywords: Depression, Mouse, Pregnancy, Seizure
Full-Text [PDF 788 kb]   (933 Downloads)    
Type of Study: Research |
Received: 2017/12/24 | Accepted: 2018/04/18 | Published: 2019/04/15
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

sabaghi A, Heyrani A, Kiani A, Yousofvand N. Effect of Seizure on the Rate of Depression in Pregnant Mice Treated with Pentylenetetrazol . J. Ilam Uni. Med. Sci. 2019; 27 (1) :104-111
URL: http://sjimu.medilam.ac.ir/article-1-4741-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 27, Issue 1 (4-2019) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
Persian site map - English site map - Created in 0.15 seconds with 40 queries by YEKTAWEB 4646