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The histopathologic effects of sulfur dioxide in mouse liver following the chronic and acute exposure
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Abstract: (16147 Views) |
| Abstract
Introduction: Sulfur dioxide (SO2) is a dangerous and poisonous gas of pollutant air in industrial countries. It is used to produce sulfuric acid and other industrial substances. Since many people are exposed to this gas daily, in this study, we examined the histopathologic effects of gas on the mouse liver in both acute and chronic exposures.
Materlals and Methods: 28 male mice were divided into 4 groups. Group1 (G1) as the control one (not exposed to gas), group2 (G2) which were exposed to high doses of sulfur dioxide (100 ppm( and group3 (G3)& group4 (G4)which were exposed to a low dose of sulfur dioxide for 5 minutes for 1 to 3 weeks(20 ppm). Finally, the mice were slaughtered. First, the livers were assessed macroscopically and then a biopsy on the livers was assessed microscopically. At last the data were analyzed statistically.
Findings: The results show that the mean number of Kupffer cells in G2, G3, and G4 significantly increased compared with the control group (9± 1.0, 10± 1.0, 11± 1.2 vs 7± 1.4: p<0.0001). Qualitative observations also show a significantly increase in the rate of liver cells necrosis and deformation of hepatic cords and sinusoids with an increase of inflammatory reactions in the experimental mice.
Conclusion: The present study indicated that the liver can be damaged by the chronic and acute exposure to sulfur dioxide. |
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| Keywords: sulfur dioxide, mouse, liver, histo-pathology |
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Full-Text [PDF 590 kb]
(3076 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2009/01/27 | Accepted: 2015/04/21 | Published: 2015/04/21
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