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:: Volume 26, Issue 4 (11-2018) ::
Journal of Ilam University of Medical Sciences 2018, 26(4): 126-135 Back to browse issues page
Plasma Changes of some Biomarkers and Adenosine Deaminase Activity in Streptozotocin-Induced Diabetes Mellitus in Rats Following Administration of Different doses of Pure Extract of Cynodon dactylon Rhizome
Farid Digaleh1 , Kaveh Azimzadeh * 2
1- Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran
2- Young Researcher and Elite Club, Urmia Branch, Islamic Azad University,Urmia, Iran , kaclinpath@gmail.com
Abstract:   (3146 Views)
Introduction: The aim of this study was to evaluate the changes of some biomarkers in streptozotocin-induced diabetic rats following the administration of pure extract of Cynodon dactylon.
 
Materials & Methods: In this study, after dividing 50 rats into five groups and induction of diabetes mellitus in four groups, pure extract of Cynodon dactylon was administered at 150, 300, and 450 mg/kg/day concentrations to three diabetic groups for three months. The positive control group (diabetic group without Cynodon dactylon administarion) along with negative control group (non-diabetic group) did not receive any extract. Afterwards, some biomarkers along with plasma adenosine deaminase (ADA) activity were assessed in all the groups.
 
Findings: The results showed a significant increase in all the inflammatory markers, including ADA Hcy, and cTnI (P≤0.01) and a significant reduction in marker of tissue damage, gelsolin (GLS), (P≤0.01) in the positive control group compared with the control group. We also found a significant decrease in these parameters (P≤0.01) and a significant increase in marker of tissue damage (GLS) following the administration of 450 mg/kg of the extract compared to the positive control and negative control groups.
 
Discussion & Conclusions: It can be concluded that the extract of Cynodon dactylon, especially at the concentration of 450 mg/kg of body weight, can significantly reduce cardiovascular and inflammatory biomarkers and elevate GLS concentration in diabetic rats.
Keywords: Cynodon dactylon, Cardiovascular biomarkers, Inflammatory markers, Diabetes mellitus
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Type of Study: Research | Subject: biochemistry
Received: 2017/08/5 | Accepted: 2018/01/8 | Published: 2018/11/15
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Digaleh F, Azimzadeh K. Plasma Changes of some Biomarkers and Adenosine Deaminase Activity in Streptozotocin-Induced Diabetes Mellitus in Rats Following Administration of Different doses of Pure Extract of Cynodon dactylon Rhizome . Journal of Ilam University of Medical Sciences 2018; 26 (4) :126-135
URL: http://sjimu.medilam.ac.ir/article-1-4495-en.html


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Volume 26, Issue 4 (11-2018) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
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