|
Evaluation of acute toxicity of Fe2NiO4 nanoparticle on biochemical parameters in rat liver
|
Rashed Golmohammadi1    , Zahra Hooshmandi * 2, Mahbubeh Setorki3 |
1- Dept of Biology, Islamic Azad University, Zanjan Branch, Zanjan, Iran
2- Dept of Biology, Islamic Azad University, Sanandaj Branch, Sanandaj, Iran , zhoushmandi@yahoo.com
3- Dept of Biology, Islamic Azad University, Izeh Branch, Izeh, Iran Abstract |
|
|
Abstract: (4856 Views) |
1.Thorek DL, Chen AK, Czupryna J, Tsourkas A. Superparamagnetic iron oxide nanoparticle probes for molecular imaging. Ann Biomed Eng 2006;34 :23-38 . doi: 10.1007/s10439-005-9002-7.
2. Shubayev VI, Pisanic TR, Jin S. Magnetic nanoparticles for theragnostics. Adv Drug Deliv Rev2009; 61:467-77 doi: 10.1016/j.addr.2009.03.007
3.Fischer H, Chan W. Nanotoxicity the growing need for in vivo study. Curr Opin Biotechnol2007;18:565-71 . doi: 10.1016/j.copbio.2007.11.008
4..Medintz I, Uyeda H, Goldman E, Mattoussi H. Quantum dot bioconjugates for imaging labelling and sensing. Nat Mate 2005;4:435-46 . doi: 10.1038/nmat1390
5.Fallahi S, Hooshmandi Z, Setorki S. [The effects of Fe4NiO4Zn nanoparticles on thyroid tissue and serum level of T3 and T4 and TSH]. J Shahrekord Unv Med Sci2017;18:115-2 .(Persian)
6.Kim J, Voon T, Yu K, Kim B, Park S. Toxicity and tissue distribution of magnetic nanoparticles in Mice. Toxicol Sci 2006;89:338-47 .
7.Jian T, Reddy M, Morales M. Biodistribution clearance and biocompability of Iron oxide magnetic nanoparticle in Rat. Mol Pharm 2008;5:127-316 doi: 10.1021/mp7001285
8.Donaldson K, Stone V, Tran C, Kreyling W, Borm PJ. Nanotoxicology. 1 th ed. BMJ Group Ltd Publication. 2003; P. 45-55 .
9.Azade N, Hushmandi Z, Setorki M. [Effect of Fe4NiO4Zn nanoparticles on serum urea Uric acid and creatinine in male Rat]. Med J Tabriz Uni2015;37:6-11 . (Persian)
10.Doudi M, Setorki M, Esmaeil N, Toodooei M, Zabih T. Effect of Fe4NiO4Zn nanoparticle on inflammatory cytokines IL6 and TNF male wistar Rat. Int J Biol Pharm All Sci 2014;2:290-300 .
11.Golmohammadi R, Hooshmandi Z, Setorki M. [The effect of Fe4NiO4Zn nanoparticles on some liver factors in wistar Rats]. J Zanjan Uni Med Sci2015;23:108-19. (Persian)
12.Peters T. Serum albumin. Adv Prote Chem1985;37:161-245 . doi: 10.1007/128_2014_598
13.Hussain S, Hess K, Gearhart J, Geiss K, Schlager J. Invitro toxicity of nanoparticles in BRL 3A Rat liver cells. Toxicol Inv 2005;19:975-83 . doi: 10.1016/j.tiv.2005.06.034
14.Babadi VY, Najafi L, Najafi A, Gholami H, Zarji MEB, Golzadeh J, et al. Evaluation of iron oxide nanoparticles effects on tissue and enzymes of liver in Rats. J Pharm Biomed Sci 2012;23:1-4 . doi: 10.5812/ircmj.28939
15.Wang L, Wang L, Ding W, Zhang F. Acute toxicity of Ferric oxide and Zinc oxide nanoparticles in Rats. J Nanosci Nanotechnol2010;10:8617-24.
16.Baek M, Chung HE, Yu J, Lee JA, Kim TH, Oh JM, et al. Pharmacokinetics tissue distribution and excretion of zinc oxide nanoparticles. Int J Nanomed2012;7:3081-97 . doi: 10.2147/IJN.S32593
17.Lei R, Wu C, Yang B, Ma H, Shi C, Wang Q, et al. Integrated metabolomic analysis of the nano-sized copper particle-induced hepatotoxicity and nephrotoxicity in Rats a rapid invivo screening method for nanotoxicity. Toxicol Appl Pharmacol2008;232:292-301 .
18.Sayes CM, Gobin AM, Ausman KD, Mendez J, West JL, Colvin VL. Nano-C 60 cytotoxicity is due to lipid peroxidation. Biomaterials2005;26:7587-95. doi: 10.1016/j.biomaterials.2005.05.027
Evaluation of acute toxicity of Fe2NiO4 nanoparticle
on biochemical parameters in rat liver
Golmohammadi R1, Hooshmandi Z2*, Setorki M3
(Received: May 2, 2017 Accepted: April 14, 2017)
Abstract
Introduction: Magnetic nanoparticles composed of iron and nickel have broad application in biological and medical sciences. Increased production and application of nanoparticles has raised concern about their negative side effects on human health. Materials & Methods: In the present study, we examined the toxicity of Fe2NiO4 nanoparticle on some biochemical parameters of rat’s liver. In this experimental study, 24 male rats were divided into three groups, including the group receiving Fe2NiO4 nanoparticles at a concentratios of 100 ppm, a group receiving the nanoparticle at a concentration of 200 ppm, and the control group. Then, 2, 7, and 14 days after the intervention, we drew blood samples from the rats and the levels of liver biochemical parameters were determined. Findings:According to the results, during the exposure period, serum albumin level was not significantly different between the groups. In the nanoparticle-treated rats, serum transferrin level showed a significant increase on the seventh day and a significant decline on the 14th day (P<0.05). Exposure of rats to the nanoparticle at the doses of 100 and 200 significantly reduced lactate dehydrogenase level compared to the control group (P<0.05). Alkaline phosphatase levels in the groups exposed to nanoparticles were not significantly different from that in the control group.
Conclusion: Results of this study indicated Fe2NiO4 cause to injury of liver.
|
|
| Keywords: Fe2Nio4, Transferrin, Albumin, Lactate dehydrogenase, Alkaline phosphatase |
|
|
Full-Text [PDF 762 kb]
(1275 Downloads)
|
Type of Study: Research |
Received: 2017/04/24 | Accepted: 2017/08/12 | Published: 2018/09/15
|
|
|
|
|
|
|
| Send email to the article author |
|
|
|
| Add your comments about this article |
|
|
|
|
|
