[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
Publication Ethics::
Peer Review Process::
Indexing Databases::
For Authors::
For Reviewers::
Subscription::
Contact us::
Site Facilities::
::
Google Scholar Metrics

Citation Indices from GS

AllSince 2019
Citations63123620
h-index2719
i10-index18679

..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Registered in

AWT IMAGE

AWT IMAGE

..
:: Volume 25, Issue 2 (7-2017) ::
Journal of Ilam University of Medical Sciences 2017, 25(2): 101-114 Back to browse issues page
Protective Effects of Simvastatin against Doxorubicin-Induced Changes in Mice Testicular Tissue
Golamreza Najafi * 1, Ali Shalizar Jalali2 , Mahla Mohammadi3
1- urmia universityDept of Basic Sciences, Faculty of Veterinary Medicine, UrmiaUniveraity, Urmia, Iran , g.najafi2006@yahoo.com
2- urmia universityDept of Basic Sciences, Faculty of Veterinary Medicine, UrmiaUniveraity, Urmia, Iran
3- Dept of Basic Sciences, Faculty of Veterinary Medicine, UrmiaUniveraity, Urmia, Iran
Abstract:   (5752 Views)

Introduction: Doxorubicin (DOX), a widely used antineoplastic compound, is associated with testicular damage and infertility. This study was carried out to disclose the possible preventive effects of simvastatin (SIM), a lipid lowering agent with antioxidant and anti-inflammatory activities, against testicular morphometric-stereological changes due to DOX treatment in mice.

Materials & methods: Male mice, five weeks old, were randomly divided into four groups of six mice each. The DOX was administered to two groups of mice in 5 equal intraperitoneal injections over a period of 4 weeks (4 mg/kg). One of these groups received 5 equal oral doses of SIM (12 mg/kg) along with DOX. A vehicle-treated control group and a SIM control group were also included. Morphometric measurement was determined using calibrated ocular micrometer.

Findings: Histomorphometrical examinations revealed significant reductions in the seminiferous tubules diameters and their epithelial heights along with an increase in testicular capsule thickness and interstitial space widening in DOX-treated mice. All above-mentioned parameters recovered significantly by SIM co-administration.

Discussion & conclusions: These results indicated that SIM may have a preventive role against morphometric-stereological changes caused by DOX in mouse testis.

Keywords: Doxorubicin, Simvastatin, Testis, Mouse
Full-Text [PDF 823 kb]   (2341 Downloads)    
Type of Study: Research |
Received: 2017/01/9 | Accepted: 2017/04/3 | Published: 2017/07/10
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Najafi G, Shalizar Jalali A, Mohammadi M. Protective Effects of Simvastatin against Doxorubicin-Induced Changes in Mice Testicular Tissue . J. Ilam Uni. Med. Sci. 2017; 25 (2) :101-114
URL: http://sjimu.medilam.ac.ir/article-1-4061-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 25, Issue 2 (7-2017) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
Persian site map - English site map - Created in 0.16 seconds with 40 queries by YEKTAWEB 4646