Introduction: Today, medicine is a strategic commodity that has a significant share of total household expenditure baskets and plays a role in the economy and the health of the family and society. Recognizing the pharmaceutical costs and its analysis help to optimize the pharmaceutical costs.
 
Materials & methods: The statistical population of the study included existing data on 61 million prescriptions in 2014 and 69 million prescriptions of insured of the Health Insurance Organization in 2015 that was sent by the pharmacy to departments of health insurance. Using existing records in the database and health insurance processor, data received from different provinces were analyzed by census method and using the software Excel 2007 and SPSS21, and results were extracted.
 
Findings: 80% of pharmaceutical costs in 2014 was used by 9.84% and in 2015 is consumed by the 8.87% of items. In 2014, drugs like interferon, insulin, Herceptin, cefixime, growth hormone, mycophenolate mofetil, Avastin, atorvastatin, Cytotoxic Mab and Tryptorlin, and in 2015, insulin, interferon, Herceptin, Avastin, cefixime, growth hormone, Factor 8, mycophenolatemofetil, atorvastatin and enoxaparin, were 10 expensive drugs to the country, respectively. In 2014 pharmaceutical groups of anti-neoplasm, anti-MS, antibiotics, antidiabetic, analgesics, immunosuppressive, growth, antihypertensives, bronchodilators and lipid lowering and in 2015 anti-neoplastic, antibiotic, anti-diabetic, anti-MS, analgesics, immunosuppressive, anti-hemophilia, blood pressure, growth and bronchodilator, were10 groups costly to the country,respectively.
 
Discussion & conclusions: Monitoring and control 10% of Pharmaceutics items can optimize 80% of pharmaceutical costs of organizations and have a considerable impact on the economy of the medicine of the country's pharmaceutical costs and medication economy.