[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Journal Information::
Articles archive::
Publication Ethics::
Peer Review Process::
Indexing Databases::
For Authors::
For Reviewers::
Contact us::
Site Facilities::
Google Scholar Metrics

Citation Indices from GS

AllSince 2019

Search in website

Advanced Search
Receive site information
Enter your Email in the following box to receive the site news and information.
Registered in



:: Volume 26, Issue 5 (1-2019) ::
Journal of Ilam University of Medical Sciences 2019, 26(5): 30-41 Back to browse issues page
Effects of Kelussia odoratissima Mozaff Hydroalcoholic Extract on Liver Injury Induced by Carbon Tetrachloride in Mice
Hoseyn Sazegar * 1, Ehsan Balali2 , Fatemeh Sadeghi Samani2
1- Islamic Azad University, Sahrekord , hoseinsazgar@yahoo.com
2- Islamic Azad University, Sahrekord
Abstract:   (3912 Views)

Introduction: Regarding the importance of liver injuries in modern societies, researchers have paid great attention to safer therapeutic products due to the side effects of chemical medicine. Klaussia odoratissima Mozaff is a herb with medicinal properties, such as antioxidant effects. This paper aimed to investigate the effect of hydroalcoholic extracts of the aerial parts of this plant (leaves and stems) on liver injury induced by carbon tetrachloride in mice.
Materials and Methods: This study was conducted on 36 male mice divide into 6 groups, including a control group, a positive control (distilled water, olive oil and carbon tetrachloride), a negative control (distilled water and olive oil), and 3 experimental groups, which received the extract (concentrations of 200, 400, and 800 mg/kg). At first, the Klaussia odoratissima Mozaff extract was administered to mice by gavage for 3 days. Afterwards, the equal proportions of olive oil and carbon tetrachloride (1 mg/kg) was administered intraperitoneally to male mice for 5 days by gavage.
Findings: Pathological findings in liver tissue indicated that apart from the control and negative control groups, there were different degrees of liver necrosis around the in all groups, more specifically in the positive control group. Study of the blood factors revealed a significant decrease of these factors in experimental groups compared to the positive control group. In addition, it was also found that the increase in the dose of extract could decrease the level of liver enzymes ALT-AST-ALP, total and direct bilirubin, and pathological damages.
Discussion & Conclusions: According to the findings of the current study it can concluded that flavonoid compounds  and  phenolic in Klaussia odoratissima  Mozaff  can decrease the toxic effects induced by carbon tetrachloride in liver tissues of  mice.

Keywords: Klaussia odoratissima Mozaff, Carbon tetrachloride, Liver enzymes, Mice
Full-Text [PDF 848 kb]   (1665 Downloads)    
Type of Study: Research | Subject: animal physiology
Received: 2016/12/19 | Accepted: 2017/08/29 | Published: 2019/01/15
Send email to the article author

Add your comments about this article
Your username or Email:


XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Sazegar H, Balali E, Sadeghi Samani F. Effects of Kelussia odoratissima Mozaff Hydroalcoholic Extract on Liver Injury Induced by Carbon Tetrachloride in Mice. J. Ilam Uni. Med. Sci. 2019; 26 (5) :30-41
URL: http://sjimu.medilam.ac.ir/article-1-4014-en.html

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 26, Issue 5 (1-2019) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
Persian site map - English site map - Created in 0.16 seconds with 41 queries by YEKTAWEB 4637