[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
Publication Ethics::
Peer Review Process::
Indexing Databases::
For Authors::
For Reviewers::
Subscription::
Contact us::
Site Facilities::
::
Google Scholar Metrics

Citation Indices from GS

AllSince 2019
Citations63203627
h-index2719
i10-index18779

..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Registered in

AWT IMAGE

AWT IMAGE

..
:: Volume 26, Issue 1 (5-2018) ::
Journal of Ilam University of Medical Sciences 2018, 26(1): 94-102 Back to browse issues page
Analyzing Association of the IRF-5 rs10954213 Gene Polymorphism with the Risk of IdiopathicRecurrent Pregnancy Losses in South Iranian Women
Rakhshan Amiri Jahromi1 , Mahboobeh Nasiri * 2
1- Dept of Biology, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran
2- Dept of Biology, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran , nasiri@iaua.ac.ir
Abstract:   (5243 Views)

Introduction: Recurrent pregnancy loss (RPL) is defined as the occurrence of two or more abortion before 20th week of gestation. The etiology of RPL is unknown in 50% of cases, which defines as idiopathic RPL (IRPL). Immune-related embryo injuries play an important role in the occurrence of RPL. Interferon regulatory factor-5 (IRF-5) is a member of IRF family of transcription factor, acts as upstream regulatory element of inflammatory cytokines (IL-6, and TNF-α). The aim of the present study was to investigate the relationship between IRF-5 gene rs10954213 polymorphism in the occurrence of IRPL.
 
Materials & Methods: In this case- control study, blood samples were collected from 176 IRPL women with a history of at least 2 miscarriages with mean age of 34.2±10.9 years as the patient group, and 173 healthy postmenopausal women with at least two live births, and without a history of previous miscarriage (mean age±SD; 56.5±7.7 years) as the control group. Genotyping was performed using T-ARMS PCR. The data were analyzed using SPSS v.16 software.
 
Findings: The frequency of G allele was lower in cases compared to control subjects. This difference was statistically significant and supported the protective effect of this allele against miscarriage (OR: 0.7, 95%CI: 0.5-0.9, p=0.04). The frequency of G carriage genotypes (GG+GA vs. AA) in women with IRPL was lower compared to the women of the control group and showed the protective role of this allele (OR:0.45, 95%CI:0.22-0.91, p-0.02).
 
Discussion & Conclusions: Regarding the results of the present study, the rs10954213G allele of the IRF-5 gene demonstrated a protective marker against idiopathic recurrent pregnancy losses in Iranian women.
 

Keywords: idiopathic recurrent pregnancy loss, polymorphism, IRF-5 gene, south Iranian women
Full-Text [PDF 744 kb]   (1358 Downloads)    
Type of Study: Research |
Received: 2016/08/14 | Accepted: 2016/12/27 | Published: 2018/05/14
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Amiri Jahromi R, Nasiri M. Analyzing Association of the IRF-5 rs10954213 Gene Polymorphism with the Risk of IdiopathicRecurrent Pregnancy Losses in South Iranian Women . J. Ilam Uni. Med. Sci. 2018; 26 (1) :94-102
URL: http://sjimu.medilam.ac.ir/article-1-3747-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 26, Issue 1 (5-2018) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
Persian site map - English site map - Created in 0.16 seconds with 40 queries by YEKTAWEB 4646