Introduction: Myocardial infarction (MI) is a leading cause of morbidity and mortality. Taurine, an essential amino acid, plays a critical role in cardiovascular function. The present study was accomplished to investigate the beneficial role of taurine on atherogenesis and atherothrombosis indexes in patients with MI.
 
Materials & Methods: In this semi-experimental study, 16 cases, 50 to 60 years old suffering from myocardial infarction were randomly classified into two experimental (taurine supplement) and placebo groups. The subjects of the experimental group took 3 supplement capsules containing 500 mg of taurine before the 3 daily meals. The placebo group took 3capsules containing starch, at the same time as the experimental members. Plasma blood sampling was carried out on the subjects at baseline level and after the modified Bruce protocol with and without taurine supplements or placebo in the same conditions.
 
Findings: There were no statistically significant differences in the general data, such as age, weight, BMI and Vo2max between the taurine supplement group and the control (P<0.05). Taurine supplementation caused significant decrease in the LDL-C/HDL-C ، TC/HDL-C، TG/HDL-C and Plate/HDL-C ratios in the supplementation and placebo groups at baseline level as well as after exhaustive exercise with modified Bruce protocol. 
 
Discussion & Conclusion: Our investigation results confirm the significance of dietary intervention in patients with MI. Taurine may be an essential candidate to enrich nutrition supports for critically ill patients, although more researches seem necessary to get at a conclusive consideration.