[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 26, Issue 1 (5-2018) ::
Journal of Ilam University of Medical Sciences 2018, 26(1): 13-22 Back to browse issues page
Effects of Cuminum cyminum Essence on Rat Ovary Function following Administration of Dopaminergic Agonist and Antagonist
Ladan Bina1, Hosein Najafzadevarzi * 2, Reza Fatemitabatabae1
1- Depat of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
2- Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran , najafzadeh@scu.ac.ir
Abstract:   (7799 Views)

Introduction: Considering the application of medicinal plants in treatment of endocrine diseases including ovarian function and also regarding the estrogenic properties of cumin (Cuminum cyminum), the present study aimed at evaluating  effects of cumin essence on oestrogen, progesterone, and ovarian follicles changes in rat at presence or absence of dopaminergic agonist and antagonist.
Materials & methods: In this experimental and animal model study, 35 female rats were divided into 7 groups which received normal saline (IP), Metoclopramide (90mg/kg-IP), Bromocriptin (4mg/kg-SC), Metoclopramide and Bromocriptin, Metoclopramide and cumin (4mg/kg-PO), cumin, Bromocriptin, and cumin for 10 days, respectively. Then, the rats were anesthetised with chloroform and their heart blood was collected for oestrogen and progesterone assessment. Afterward,  ovaries and uterines were removed and weighted and the immature and mature follicles were counted.
Findings: The results showed that metoclopramide decreases oestrogen and progesterone concentration and bromocriptin administration can reverse its effect. On the other hand, cumin application proved to  decrease the weight of the rats and serum oestrogen concentration. Co-administration of cumin and bromocriptin increased oestrogen concentration and the numbers of folliculars.
Discussion & conclusions: Cumin usage can accelerate the effects of bromocriptin as a dopaminergic on ovarian function.

Keywords: oestrogen, progesterone, bromocriptin, metoclopramide, cuminum cyminum, ovary, rat
Full-Text [PDF 1066 kb]   (7042 Downloads)    
Type of Study: Research |
Received: 2016/05/13 | Accepted: 2016/11/27 | Published: 2018/05/1
Send email to the article author

Add your comments about this article
Your username or Email:


XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Bina L, Najafzadevarzi H, Fatemitabatabae R. Effects of Cuminum cyminum Essence on Rat Ovary Function following Administration of Dopaminergic Agonist and Antagonist . Journal of Ilam University of Medical Sciences 2018; 26 (1) :13-22
URL: http://sjimu.medilam.ac.ir/article-1-3539-en.html

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 26, Issue 1 (5-2018) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
Persian site map - English site map - Created in 0.14 seconds with 30 queries by YEKTAWEB 4541