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:: Volume 25, Issue 2 (7-2017) ::
Journal of Ilam University of Medical Sciences 2017, 25(2): 82-90 Back to browse issues page
Frequency of Extended Spectrum Beta Lactamase Producing Multidrug Resistant Klebsiells Pnemoniae in Urinary Tract Infections in Rasht
Leila Asadpour * 1, Maryam Nahavandinejhad2
1- Dept of Veterinary Science, Faculty of Agricultural Sciences, Islamic Azad University, Rasht Branch, Rasht, Iran , l.asadpour@yahoo.com
2- Dept of Biology, Faculty of Basic Sciences, Islamic Azad University, Rasht Branch, Rasht, Iran
Abstract:   (9156 Views)

Introduction: Klebsiella pnemoniae is an opportunistic microorganism which is one of the most important causes of urinary infections. The present study aimed to investigate the frequency of extended spectrum beta lactamase producing and multi drug resistant K. pnemoniae in urinary tract infections.

Materials & methods: A total of 340 urine samples were analyzed for the presence of K. pnemoniae. Drug resistance pattern of the K. pnemoniae isolates and production of extended spectrum beta lactamase (ESBL) were determined by agar disc diffusion and combined disc methods. Frequency of TEM and SHV genes in ESBL positive strains was determined by PCR.

Findings: Out of 340 urine samples, in 65 (19.12%) samples K. pnemoniae were isolated as the causative agent of urinary tract infections. All of the isolates showed multi drug resistance and the most resistance was against penicillin (92%), amoxicillin (87.6%), and erythromycin (84.6%). Gentamycin and kanamycin showed the most antibacterial effects. Also, 32 (52.3%) of tested bacteria were recognized as extended spectrum beta lactamase producer isolates. Out of them 26 (76%) isolates were identified positive for the presence of TEM gene and 15 (44%) isolates were SHV positive.

 Discussion & conclusions: The results showed a high prevalence of K. pnemoniae in urinary tract infections and high amounts of drug resistance in the isolates.

Keywords: Drug resistance, Klebsiella pnemoniae, SHV, TEM, Urinay infection
Full-Text [PDF 579 kb]   (2490 Downloads)    
Type of Study: Research |
Received: 2016/05/2 | Accepted: 2016/06/13 | Published: 2017/07/10
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Asadpour L, Nahavandinejhad M. Frequency of Extended Spectrum Beta Lactamase Producing Multidrug Resistant Klebsiells Pnemoniae in Urinary Tract Infections in Rasht. J. Ilam Uni. Med. Sci. 2017; 25 (2) :82-90
URL: http://sjimu.medilam.ac.ir/article-1-3527-en.html


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Volume 25, Issue 2 (7-2017) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
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