Introduction: Epilepsy is a neurological disease which can cause psychological problems for people suffering from it. The aim of this research was to investigate the effectiveness of acceptance and commitment therapy on psychological well- being in people with epilepsy.

Materials & methods: In the current research, semi-experimental design with the method of pre-test and post-test and a 2 month follow up with control group and convenience sampling method were used. Research population was the people suffering from epilepsy referring to Imam Hossein hospital in the autumn and winter of 1394. Among these people, 32 individuals fitting the research criteria were chosen and put randomly in the control and experiment group. The individuals of experiment group were under acceptance and commitment treatment in 10 sessions each of which last 75 minutes. The tool for doing this research was Ryff (1989) questionnaire consisting of 84 questions, and its data were analyzed by Spss-21 software.

Findings: The analysis of multi-variant co-variance showed that the acceptance and commitment therapy had a significant effect on the on psychological well- being in people with epilepsy. Also, the effects of this therapy lasted for 2 months (0/01).

Discussion & conclusions: The results of the study indicated that the acceptance and commitment therapy was efficient in the improvement of the psychological wellbeing of patients with epilepsy. Thus, the use of this therapy is recommended in order to improve the psychological wellbeing of the patients suffering from epilepsy.