[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
Publication Ethics::
Peer Review Process::
Indexing Databases::
For Authors::
For Reviewers::
Subscription::
Contact us::
Site Facilities::
::
Google Scholar Metrics

Citation Indices from GS

AllSince 2019
Citations67814025
h-index2721
i10-index20297

..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Registered in

AWT IMAGE

AWT IMAGE

..
:: Volume 25, Issue 2 (7-2017) ::
Journal of Ilam University of Medical Sciences 2017, 25(2): 166-172 Back to browse issues page
Evaluating the Prevalence of Plasminogen Activator Inhibitor-1 Gene Polymorphism in Patients with Thyroid Tumors from North West of Iran
Mahdieh Younesi1 , Mohammadali Hosseinpour Feizi * 2, Nasser Pouladi3
1- Dept of Animal Biology, Faculty of Natural Sciences, Tabriz University,Tabriz, Iran
2- Dept of Animal Biology, Faculty of Natural Sciences, Tabriz University,Tabriz, Iran , pourfeizi@eastp.ir
3- Dept of Biology, Faculty of Sciences, Azarbaijan Shahid Madani University, Tabriz, Iran
Abstract:   (4942 Views)

Introduction: Association of PAI-1 polymorphisms with the increased risk of various malignancies has been shown in numerous studies. Therefore, the aim of the current study is to evaluate the prevalence of PAI-1 4G/5G polymorphism in patients with thyroid tumors from North West of Iran.

Materials & methods: Ninety patients with thyroid tumors and 180 healthy controls were selected from North West of Iran. DNA was extracted from peripheral blood samples and 4G/5G polymorphism of the PAI-1 gene was evaluated by polymerase chain reaction using specific primers.

Findings: Genotype distribution between patients was (4G/4G=13.33%, 4G/5G=63.33% and 5G/5G=23.33%) and controls (4G/4G=17.22%, 4G/5G=67.22% and 5G/5G=15.55%). Additionally, the frequencies of the 4G and 5G alleles between patients were (45% and 55%) and control group (50.83% and 49.16%).

Discussion & conclusions: Results indicate that the genotypic and allelic frequencies of PAI-1 4G/5G polymorphism showed no significant difference between patients with thyroid tumors and control individuals in this cohort.

Keywords: Polymorphism, Plasminogen activation system, Thyroid tumors
Full-Text [PDF 353 kb]   (1863 Downloads)    
Type of Study: Research |
Received: 2015/12/16 | Accepted: 2016/02/14 | Published: 2017/07/18
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Younesi M, Hosseinpour Feizi M, Pouladi N. Evaluating the Prevalence of Plasminogen Activator Inhibitor-1 Gene Polymorphism in Patients with Thyroid Tumors from North West of Iran. J. Ilam Uni. Med. Sci. 2017; 25 (2) :166-172
URL: http://sjimu.medilam.ac.ir/article-1-3252-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 25, Issue 2 (7-2017) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
Persian site map - English site map - Created in 0.15 seconds with 40 queries by YEKTAWEB 4666